替硝唑合剂与甲醛甲酚联合封管治疗慢性牙髓炎的有效性及安全性分析

Effectiveness and Safety Analysis of the Combination of Tinidazole Mixture and Formaldehyde Cresol in the Treatment of Dental Pulp Disease

目的探讨替硝唑合剂与甲醛甲酚联合封管治疗慢性牙髓炎的有效性及安全性。方法选取2020年5月—2022年6月该院收治的80例慢性牙髓炎患者为研究对象,按照随机数字表法将其分为对照组和观察组,每组40例。两组均予以根管治疗,于此基础上对照组使用甲醛甲酚进行封管,观察组使用甲醛甲酚联合替硝唑合剂进行封管。比较两组临床疗效、咀嚼功能、炎症因子、不良反应发生情况。结果观察组治疗总有效率97.50%高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,观察组的咬合力(143.02±8.97)lbs、咀嚼效率(88.05±6.14)%均高于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组C反应蛋白水平(9.14±2.67)mg/mL、白细胞介素水平(1.01±0.10)ng/mL、不良反应发生率5.00%均低于对照组,组间差异有统计学意义(P<0.05)。结论甲醛甲酚联合替硝唑合剂进行封管效果更佳,能促进咀嚼功能改善,降低炎症水平,降低不良反应发生率。

Objective To explore the effectiveness and safety of tinidazole mixture combined with formaldehyde cresol in the treatment of chronic pulpitis.Methods A total of 80 patients with chronic pulpitis admitted to the hospital from May 2020 to June 2022 were selected as the research subjects.They were randomly divided into a control group and an observation group using a random number table method,with 40 patients in each group.Both groups were treated with root canal therapy.On this basis,the control group was sealed with formaldehyde cresol,while the observation group was sealed with formaldehyde cresol combined with tinidazole mixture.The clinical efficacy,chewing function,inflammatory factors,and occurrence of adverse reactions between two groups were compared.Results The total effective rate of the observation group was 97.50%,which was higher than 75.00%of the control group,the difference was statistically significant(P<0.05).After treatment,the bite force(143.02±8.97)lbs and masticatory efficiency(88.05±6.14)%of the observation group were higher than those of control group,the differences were statistically significant(P<0.05).After treatment,the C-reactive protein(9.14±2.67)mg/mL,interleukin(1.01±0.10)ng/mL and the incidence of adverse reactions 5.00%in observation group were lower than those in the control group,with statistical significance(P<0.05).Conclusion Formalcresol combined with tinidazole mixture has better sealing effect,which can improve masticatory function,reduce inflammation level,reduce the incidence of adverse reactions.