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氨溴索联合布地奈德雾化吸入治疗新生儿肺炎的临床效果

Clinical Efficacy of Ambroxol Combined with Budesonide Nebulized Inhalation in the Treatment of Neonatal Pneumonia
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摘要 目的研究氨溴索联合布地奈德雾化吸入治疗新生儿肺炎的临床效果。方法选取我院2018年6月—2023年6月收治的60例新生儿肺炎患儿为研究对象,按随机数字表法将其分为对照组与试验组,各30例。对照组采用布地奈德雾化吸入治疗,试验组采用氨溴索联合布地奈德雾化吸入治疗。对比两组的临床疗效、胸部影像学好转率、炎症因子指标水平、不良反应发生情况。结果试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。试验组胸部影像学好转率高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组C反应蛋白、白细胞介素-6、白细胞计数水平均低于对照组,组间差异有统计学意义(P<0.05)。两组均未出现严重不良反应。结论氨溴索联合布地奈德雾化吸入治疗新生儿肺炎的效果显著,患儿胸部影像学检查结果得以改善,炎性反应有所减轻,治疗安全性较高。 Objective Study on the clinical effect of ambroxol combined with budesonide nebulized inhalation in the treatment of neonatal pneumonia.Methods Selecting 60 newborns with pneumonia admitted to our hospital from June 2018 to June 2023 as the research subjects,divide them into a control group and an experimental group using a random number table method,with 30 cases in each group.The control group was given budesonide atomization nebulized inhalation treatment,and the experimental group was given ambroxol combined with budesonide nebulized inhalation treatment.The clinical efficacy,conversion rate of chest imaging,levels of inflammatory factor indicators,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,the differences was statistically significant(P<0.05).The conversion rate of chest imaging in the experimental group was higher than that in the control group,the differences was statistically significant(P<0.05).After treatment,the levels of C-reactive protein,interleukin-6,and white blood cell count in the experimental group were lower than those in the control group,the differences between groups were statistically significant(P<0.05).Neither group experienced serious adverse reactions.Conclusion The combination of ambroxol and budesonide nebulized inhalation has a significant effect on the treatment of neonatal pneumonia,the chest imaging examination results of the patient have been improved,the inflammatory response has been alleviated,and the treatment safety is relatively high.
作者 黄艳华 HUANG Yanhua(Department of Pediatrics,Jining Third People's Hospital(Yanzhou District People's Hospital),Jining 272100,China)
出处 《反射疗法与康复医学》 2024年第16期96-98,共3页 Reflexology And Rehabilitation Medicine
关键词 新生儿肺炎 氨溴索 布地奈德 胸部影像学 Neonatal pneumonia Ambroxol Budesonide Chest imaging
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