低分子量肝素钠联合硫酸镁及拉贝洛尔对重度妊娠期高血压患者血压水平、凝血功能及妊娠结局的影响

Effects of Low Molecular Weight Heparin Sodium Combined with Magnesium Sulfate and Rabelol on Blood Pressure Levels,Coagulation Function and Pregnancy Outcomes in Patients with Severe Hypertension in Pregnancy

目的探讨低分子量肝素钠联合硫酸镁及拉贝洛尔对重度妊娠期高血压(HIP)患者血压水平、凝血功能及妊娠结局的影响。方法选取青岛市城阳区人民医院产科2020年8月—2023年8月收治的84例重度HIP患者为研究对象,采用随机数字表法将其分为对照组和观察组,每组42例。对照组采取硫酸镁及拉贝洛尔治疗,观察组在对照组基础上采取低分子量肝素钠进行治疗,两组均持续治疗1周,并随访至分娩后。对比两组血压水平、凝血功能、不良妊娠结局及不良反应发生率。结果治疗后,观察组收缩压、舒张压水平均低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组凝血活酶时间、凝血酶原时间均长于对照组,纤维蛋白原水平低于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率为7.14%,低于对照组的23.81%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论低分子量肝素钠联合硫酸镁及拉贝洛尔能够有效降低重度HIP患者的血压水平,改善凝血功能及妊娠结局,且不良反应较少。

Objective To explore the effects of low molecular weight heparin sodium combined with magnesium sulfate and rabelol on blood pressure levels,coagulation function,and pregnancy outcomes in patients with severe hypertension in pregnancy(HIP).Methods A total of 84 severe HIP patients admitted to the Department of Obstetrics and Gynecology Qingdao Chengyang District People's Hospital from August 2020 to August 2023 were selected as the study subjects.They were randomly divided into a control group and an observation group using a random number table method,with 42 cases in each group.The control group received treatment with magnesium sulfate and rabelol,while the observation group received treatment with low molecular weight heparin sodium on the basic of the control group;both group were treated for one week and followed up until delivery.blood pressure levels,coagulation function,adverse pregnancy outcomes,and incidence of adverse reactions between two groups were compared.Results After treatment,the average systolic and diastolic blood pressure in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,longer thrombin time and prothrombin time of the observation group were longer than those of the control group,and the fibrinogen level was lower than that of the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 7.14%,which was lower than 23.81%in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions between the two groups of patients was compared,the difference was not statistically significant(P>0.05).Conclusion Low molecular weight heparin sodium combined with magnesium sulfate and rabelol can effectively reduce blood pressure levels,improve coagulation function and pregnancy outcomes in patients with severe HIP,and have fewer adverse reactions.