硝苯地平联合硫酸镁在妊娠期高血压患者中的应用效果

Therapeutic Effect of Nifedipine Combined with Magnesium Sulfate in the Treatment of Gestational Hypertension Patients

目的探讨硝苯地平联合硫酸镁在妊娠期高血压(HDP)患者中的治疗效果。方法选取2021年3月—2023年3月我院收治的168例HDP患者为研究对象,按随机数字表法将其分为对照组和观察组,各84例。对照组采用硫酸镁治疗,观察组在对照组基础上加用硝苯地平治疗。对比两组临床疗效、血压指标、血清学指标、妊娠结局及安全性。结果观察组治疗总有效率95.24%高于对照组的84.52%,差异有统计学意义(P<0.05)。治疗7 d后,观察组收缩压(132.20±7.75)mmHg、舒张压(86.36±6.61)mmHg、同型半胱氨酸(10.33±1.46)μmol/L、C反应蛋白(6.21±1.13)mg/L、内皮素-1(42.46±4.33)ng/L水平均低于对照组的(144.35±8.64)mmHg、(93.28±7.45)mmHg、(13.24±2.03)μmmol/L、(8.02±1.27)mg/L、(47.68±4.12)ng/L,一氧化氮水平高于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率5.95%低于对照组的15.48%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论硝苯地平联合硫酸镁应用于HDP患者治疗中,可以增强血压控制效果,改善血清学指标,减少不良妊娠结局,安全性良好。

Objective To explore the therapeutic effect of Nifedipine combined with Magnesium sulfate in patients with gestational hypertension(HDP).Methods A total of 168 patients with HDP admitted to our hospital from March 2021 to March 2023 were selected as the study objects and randomly divided into a control group and an observation group,with 84 cases in each group,using a random number table method.The control group was treated with magnesium sulfate,while the observation group was treated with nifedipine in addition to the control group.The clinical efficacy,blood pressure indicators,serological indicators,pregnancy outcomes,and safety between two groups were compared.Results The total effective rate of the observation group was 95.24%,which was higher than 84.52%of the control group,the difference was statistically significant(P<0.05).Seven days after treatment,the levels of systolic blood pressure(132.20±7.75)mmHg,diastolic blood pressure(86.36±6.61)mmHg,homocysteine(10.33±1.46)μmol/L,C-reactive protein(6.21±1.13)mg/L,and endothelin-1(42.46±4.33)ng/L in the observation group were lower than(144.35±8.64)mmHg,(93.28±7.45)mmHg,(13.24±2.03)μmol/L,(8.02±1.27)mg/L,(47.68±4.12)ng/L in the control group,the level of nitric oxide in the observation group was higher than that in the control group,the differences between the two groups were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 5.95%,which was lower than 15.48%in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of nifedipine and magnesium sulfate can enhance the blood pressure control effect of HDP,improve serological indicators,reduce adverse pregnancy outcomes,and have high safety.