卡前列素氨丁三醇联合宫腔球囊放置术治疗前置胎盘产后出血的临床效果

Clinical Effect of Carboprost Tromethamine Combined with Balloon Placement in the Treatment of Placenta Previa Postpartum Hemorrhage

目的探讨卡前列素氨丁三醇素联合宫腔球囊放置术治疗前置胎盘产后出血的临床效果。方法选取成武县人民医院2018年1月—2021年12月收治的72例前置胎盘产后出血患者为研究对象,按随机数字表法分为对照组及观察组,每组36例。两组均行宫腔球囊放置术,在此基础上,对照组采用缩宫素治疗,观察组采用卡前列素氨丁三醇治疗。比较两组患者的止血效果、出血情况、凝血功能及生命体征。结果观察组的止血总有效率为94.44%,高于对照组的77.78%,差异有统计学意义(P<0.05)。观察组的产后2、6、12、24 h出血量分别为(385.25±34.16)mL、(658.41±50.24)mL、(862.41±75.41)mL、(1089.65±105.25)mL,均少于对照组的(425.35±45.41)mL、(708.63±52.47)mL、(928.47±80.36)mL、(1254.63±125.74)mL,组间差异有统计学意义(P<0.05)。治疗24 h后,观察组的凝血酶原时间、活化部分凝血活酶时间分别为(11.53±1.22)s、(37.05±3.12)s,均短于对照组的(13.42±1.25)s、(40.18±3.85)s,组间差异有统计学意义(P<0.05)。治疗24 h后,观察组的收缩压、舒张压均高于对照组,心率慢于对照组,组间差异有统计学意义(P<0.05)。结论卡前列素氨丁三醇联合宫腔球囊放置术的止血效果更佳,可减少前置胎盘患者的产后出血量,改善其凝血功能,稳定其心率及血压。

Objective To investigate the clinical effect of carboprost tromethamine combined with balloon placement in the treatment of placenta previa postpartum hemorrhage.Methods A total 72 placenta previa patients with postpartum hemorrhage admitted to Chengwu County People's Hospital from January 2018 to December 2021 were selected as the study objects and were divided into a control group and an observation group according to random number table method,with 36 cases in each group.Uterine balloon placement was performed in both groups.On this basis,the control group was treated with oxytocin,and the observation group was treated with carboprost tromethamine.The hemostatic effect,bleeding situation,coagulation function and vital signs of the two groups were compared.Results The total effective rate of hemostasis in the observation group was 94.44%,which was higher than 77.78%in the control group,the difference was statistically significant(P<0.05).The postpartum blood loss at 2,6,12 and 24 h in the observation group were(385.25±34.16)mL,(658.41±50.24)mL,(862.41±75.41)mL and(1089.65±105.25)mL,respectively,which were less than(425.35±45.41)mL,(708.63±52.47)mL,(928.47±80.36)mL and(1254.63±125.74)mL in the control group,the differences between the groups were statistically significant(P<0.05).After 24 h of treatment,the prothrombin time and activated partial thromboplastin time in the observation group were(11.53±1.22)s and(37.05±3.12)s,respectively,which were shorter than(13.42±1.25)s and(40.18±3.85)s in the control group,the differences between the two groups were statistically significant(P<0.05).After 24 h of treatment,the systolic blood pressure and diastolic blood pressure in the observation group were higher than those in the control group,and the heart rate was slower than that in the control group,the differences between the two groups were statistically significant(P<0.05).Conclusion Carboprost tromethamine combined with balloon placement has better hemostatic effect,can reduce postpartum blood loss,improve coagulation function,and stabilize heart rate and blood pressure in placenta previa patients.