乌司他丁辅助生长抑素对重症急性胰腺炎患者肠道黏膜屏障功能及炎症指标的影响

Effect of Ulinastatin Assisted Somatostatin on Intestinal Mucosal Barrier Function and Inflammatory Indicators in Patients with Severe Acute Pancreatitis

目的分析乌司他丁辅助生长抑素在重症急性胰腺炎(SAP)患者中的应用效果。方法选取山东国欣颐养集团枣庄医院2021年4月—2023年4月收治的80例SAP患者为研究对象,按随机数字表法将其分为对照组和观察组,每组40例。两组均给予内科常规治疗,其中对照组采用生长抑素治疗,观察组在对照组的基础上采用乌司他丁治疗,均连续用药14 d。比较两组临床疗效、肠道炎症反应、肠道黏膜屏障功能及不良反应发生情况。结果观察组治疗总有效率为97.50%,高于对照组77.50%,差异有统计学意义(P<0.05)。治疗后,观察组肠道炎症反应指标水平、肠道黏膜屏障功能指标水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论乌司他丁辅助生长抑素治疗SAP的效果较佳,有利于降低机体炎症介质水平,增强肠道黏膜屏障功能,且具有较好的应用安全性。

Objective To analyze the effect of ulinastatin assisted somatostatin in patients with severe acute pancreatitis(SAP).Methods A total of 80 SAP patients admitted to Zaozhuang Hospital of Shandong Guoxin Health Nursing Group from April 2021 to April 2023 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 40 cases in each group.Both groups were given routine medical treatment,among which the control group was treated with somatostatin,and the observation group was treated with ulinastatin on the basis of the control group,for 14 days in a row.The clinical efficacy,intestinal inflammatory reaction,intestinal mucosal barrier function and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.50%,which was higher than 77.50%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of intestinal inflammatory response indexes and intestinal mucosal barrier function indexes in the observation group were lower than those in the control group,the differences between the two groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of ulinastatin assisted somatostatin in the treatment of SAP is better,which is beneficial to reduce the level of inflammatory mediators in the body,enhance the intestinal mucosal barrier function,and has good application safetyx.