布地奈德与复方异丙托溴铵联合应用于小儿细菌性支气管肺炎临床治疗中的效果观察

Observation on the Effect of Combination of Budesonide and Compound Ipratropium Bromide in the Clinical Treatment of Children with Bacterial Bronchopneumonia

目的探讨布地奈德、复方异丙托溴铵联合治疗小儿细菌性支气管肺炎的临床效果。方法选取本院2023年1—12月收治的80例细菌性支气管肺炎患儿为研究对象,按随机数字表法将其分为对照组与观察组,各40例。对照组采用常规治疗,观察组采用布地奈德、复方异丙托溴铵联合治疗。对比两组临床疗效、炎症指标水平、症状改善时间与住院时间、不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞计数、中性粒细胞百分比、C反应蛋白水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组症状改善时间、住院时间均短于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论布地奈德与复方异丙托溴铵联合治疗小儿细菌性支气管肺炎具有较佳疗效,能有效降低炎症指标水平,缩短症状改善及住院时间,促进患儿恢复,且安全性良好。

Objective To investigate the clinical effect of budesonide and compound ipratropium bromide in the treatment on children with bacterial bronchopneumonia.Methods A total of 80 children with bacterial bronchopneumonia admitted to our hospital from January to December 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 40 cases in each group.The control group received conventional treatment,the observation group received budesonide and compound ipratropium bromide combined treatment.The clinical efficacy,inflammation index level,symptom improvement time,hospital stay and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the white blood cell count,neutrophil percentage and C-reactive protein levels in the two groups were lower than before treatment,and the observation group was lower than the control group,the differences between the groups were statistically significant(P<0.05).The symptom improvement time and hospitalization time in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of budesonide and compound ipratropium bromide in the treatment of children with bacterial bronchophenitis has a good effect,can effectively reduce the level of inflammation indicators,is conducive to shortening symptoms and hospital stay,and promote the recovery of children,and has good safety.