阿奇霉素序贯疗法联合特布他林雾化吸入对支原体肺炎患儿肺功能及血清炎症因子水平的影响

Effect of Azithromycin Sequential Therapy Combined with Terbutaline Nebulization Inhalation on Pulmonary Function and Serum Inflammatory Factor Levels in Children with Mycoplasma Pneumonia

目的探讨支原体肺炎(MP)患儿采用阿奇霉素序贯疗法联合特布他林雾化吸入治疗的效果。方法选择山东省泗水县人民医院2023年2—8月收治的102例MP患儿为研究对象,按随机数字表法将其分为对照组和观察组,每组51例。两组均接受常规对症治疗,在此基础上,对照组采用阿奇霉素序贯疗法,观察组采用阿奇霉素序贯疗法联合特布他林雾化吸入,两组均持续治疗7 d。对比两组患儿的肺功能、血清炎症因子水平、临床疗效及不良反应发生情况。结果治疗后,观察组的各项肺功能指标水平均高于对照组,各项血清炎症因子水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组的治疗总有效率为96.08%,高于对照组的84.31%,差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用阿奇霉素序贯疗法联合特布他林雾化吸入治疗MP患儿,可改善其肺功能,减轻炎症反应,疗效显著,且应用安全性较好,值得临床推广使用。

Objective To investigate the effect of azithromycin sequential therapy combined with terbutaline nebulization inhalation in children with mycoplasma pneumonia(MP).Methods A hundred and two cases of children with MP admitted to Sishui County People's Hospital,Shandong Province from February to August 2023 were selected as the research objects and were divided into a control group and an observation group according to random number table method,with 51 cases in each group.Both groups received conventional symptomatic treatment.On this basis,the control group was treated with azithromycin sequential therapy,and the observation group was treated with azithromycin sequential therapy combined with terbutaline nebulization inhalation.Both groups were treated continuously for 7 days.The pulmonary function,serum inflammatory factor levels,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the levels of pulmonary function indexes in the observation group were higher than those in the control group,and the levels of serum inflammatory factors were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).The total effective rate of the observation group was 96.08%,which was higher than 84.31%of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Azithromycin sequential therapy combined with terbutaline nebulization inhalation in the treatment of MP children can improve pulmonary function and reduce inflammation,with significant efficacy and good safety,and is worthy of clinical promotion.