硝苯地平联合硫酸镁治疗对子痫前期患者胎盘血流灌注参数、血压水平的影响分析

Effects of Nifedipine Combined with Magnesium Sulfate on Placental Blood Perfusion Parameters and Blood Pressure in Patients with Preeclampsia

目的探讨硝苯地平联合硫酸镁治疗对子痫前期(PE)患者胎盘血流灌注参数、血压水平的影响。方法选取2022年2月—2023年8月曹县人民医院收治的60例PE患者为研究对象,按随机数字表法将其分为对照组和观察组,各30例。对照组采取硫酸镁治疗,观察组在对照组的基础上采取硝苯地平治疗,两组均治疗1周,并观察至患者分娩。对比两组的血清学指标、胎盘血流灌注参数、血压水平、妊娠结局及不良反应发生情况。结果治疗后,观察组血清胱抑素低于对照组,人体细胞抗原高于对照组,组间差异有统计学意义(P<0.05);观察组血管化-血流指数、血管化指数、血流指数均高于对照组,组间差异有统计学意义(P<0.05);观察组收缩压及舒张压均低于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率为3.33%,低于对照组的26.67%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论硝苯地平联合硫酸镁治疗PE患者的效果显著,有利于改善其血清学指标及胎盘血流灌注参数,可调节血压水平,获得更良好的妊娠结局。

Objective To investigate the effects of nifedipine combined with magnesium sulfate on placental blood perfusion parameters and blood pressure in patients with preeclampsia(PE).Methods Sixty PE patients admitted to Caoxian People's Hospital from February 2022 to August 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with nifedipine on the basis of the control group.Both groups were treated for 1 week,and delivery was observed.Serological indexes,placental blood perfusion parameters,blood pressure,pregnancy outcome and adverse reactions were compared between the two groups.Results After treatment,the serum cystatin of observation group was lower than that of control group,and the human cell antigen was higher than that of control group,the differences between the groups were statistically significant(P<0.05);vascularization-blood flow index,vascularization index and blood flow index in observation group were higher than those in control group,and the differences between the groups were statistically significant(P<0.05).The systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).The total incidence of adverse pregnancy outcome in the observation group was 3.33%,which was lower than 26.67%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Nifedipine combined with magnesium sulfate is effective in the treatment of PE patients,which is conducive to improving serological indexes and placental blood perfusion parameters,regulating blood pressure level,and obtaining better pregnancy outcome.