养心安神汤联合西医基础治疗对慢性心衰气阴两虚证伴失眠患者运动耐力、睡眠质量的影响

Effect of Yangxin Anshen Decoction Combined with Western Medicine Basic Treatment on Exercise Endurance and Sleep Quality of Patients with Chronic Heart Failure Syndrome of Qi-Yin Deficiency Syndrome Accompanied by Insomnia

目的探讨养心安神汤联合西医基础治疗在慢性心力衰竭(CHF)气阴两虚证伴失眠患者中的应用效果。方法选取2021年3月—2023年3月南通市通州区中医院收治的64例CHF气阴两虚证伴失眠患者为研究对象,按随机数字表法将其分为对照组和观察组,各32例。对照组采用西医基础治疗,观察组在对照组基础上联合养心安神汤治疗,两组均持续治疗8周。对比两组的临床疗效、运动耐力、睡眠质量、心功能及中医证候积分。结果观察组治疗总有效率为93.75%,高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,观察组6 min步行距离远于对照组,差异有统计学意义(P<0.05);观察组匹兹堡睡眠质量指数各个维度评分均低于对照组,组间差异有统计学意义(P<0.05);观察组氨基末端脑钠肽前体蛋白水平低于对照组,左室射血分数、每搏输出量水平均高于对照组,组间差异有统计学意义(P<0.05);观察组中医证候积分低于对照组,差异有统计学意义(P<0.05)。结论养心安神汤联合西医基础治疗CHF气阴两虚证伴失眠的效果较好,能够有效减轻患者临床症状,改善睡眠质量与心功能,提升运动耐力。

Objective To investigate the effect of Yangxin Anshen Decoction combined with Western medicine in chronic heart failure(CHF)patients with insomnia due to Qi-Yin deficiency syndrome.Methods A total of 64 patients with CHF syndrome of Qi-Yin deficiency and insomnia treated in Tongzhou District Hospital of Traditional Chinese Medicine of Nantong City from March 2021 to March 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 32 cases in each group.The control group was given basic Western medicine treatment,and the observation group was combined with Yangxin Anshen Decoction on the basis of the control group,both groups were treated for 8 weeks.The clinical efficacy,exercise endurance,sleep quality,heart function and TCM syndrome scores were compared between the two groups.Results The total effective rate of the observation group was 93.75%,which was higher than 75.00%of the control group,the difference was statistically significant(P<0.05);after treatment,the 6-min walking distance of the observation group was much longer than that of the control group,and the difference was statistically significant(P<0.05);all the scores of Pittsburgh Sleep Quality Index in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05);the level of amino terminal brain natriuretic peptide precursor protein in the observation group was lower than that in the control group,and the level of left ventricular ejection fraction and stroke output were higher than that in the control group,and the differences between the groups were statistically significant(P<0.05).The TCM syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Yangxin Anshen Decoction combined with Western medicine has a good effect on the treatment of CHF Qi-Yin deficiency syndrome accompanied by insomnia,which can effectively reduce the clinical symptoms of patients,improve sleep quality and heart function,and enhance exercise endurance.