经脐单孔与多孔腹腔镜手术对子宫肌瘤患者围术期指标及炎症-氧化应激指标的影响对比

Comparison of Perioperative Indicators and Inflammatory-Oxidative Stress Indicators in Patients with Uterine Fibroids after Transumbilical Single-Port and Multi-Port Laparoscopic Surgery

目的探讨经脐单孔与多孔腹腔镜手术在子宫肌瘤患者中的治疗效果。方法回顾性分析2022年10月—2024年2月临沂市中心医院收治的98例子宫肌瘤患者的临床资料,按手术方法不同分为对照组和观察组,各49例。对照组行多孔腹腔镜手术,观察组行经脐单孔腹腔镜手术。对比两组的围术期指标、疼痛程度及炎症-氧化应激指标。结果观察组术中出血量为(36.73±4.19)mL,少于对照组的(50.62±5.10)mL,手术时间为(65.41±5.89)min、术后排气时间为(12.19±3.16)h、住院时间为(4.68±0.50)d,均短于对照组的(72.73±6.70)min、(20.44±3.27)h、(5.79±0.67)d,组间差异有统计学意义(P<0.05);术后24 h及术后48 h,观察组疼痛视觉模拟评分均低于对照组,组间差异有统计学意义(P<0.05);术后24 h,观察组肿瘤坏死因子-α、C反应蛋白、白细胞介素-6、丙二醛水平均低于对照组,超氧化物岐化酶水平高于对照组,组间差异有统计学意义(P<0.05)。结论与多孔腹腔镜手术相比,经脐单孔腹腔镜手术治疗子宫肌瘤的临床效果更好,更有利于患者术后恢复,且炎症反应更少,疼痛程度更轻。

Objective To investigate the therapeutic effect of transumbilical single-port and multi-port laparoscopic surgery in patients with uterine fibroids.Methods The clinical data of 98 patients with uterine fibroids in Linyi Central Hospital from October 2022 to February 2024 were retrospectively analyzed,according to different surgical methods,they were divided into control group and observation group,with 49 cases in each group.The control group underwent multi-port laparoscopic surgery,and the observation group underwent transumbilical single-port laparoscopic surgery.Perioperative indicators,pain degree and inflammatory-oxidative stress indicators were compared between the two groups.Results The intraoperative blood loss in the observation group was(36.73±4.19)mL,which was less than(50.62±5.10)mL in the control group,the operative time was(65.41±5.89)min,the postoperative exhaust time was(12.19±3.16)h,and the length of hospitalization was(4.68±0.50)d,which were shorter than(72.73±6.70)min,(20.44±3.27)h,(5.79±0.67)d of control group,and the differences between the groups were statistically significant(P<0.05);at 24 hours and 48 hours after operation,the pain Visual Analogue Scale scores of the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05);24 hours after operation,the levels of tumor necrosis factor-α,C-reactive protein,interleukin-6 and malondialdehyde in observation group were lower than those in control group,and the levels of superoxide dismutase were higher than those in control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Compared with porous laparoscopic surgery,transumbilical single-hole laparoscopic surgery has better clinical effect in the treatment of uterine fibroids,is more conducive to postoperative recovery of patients,and has less inflammation and less pain.