盐酸利托君联合经腹羊膜腔灌注术对未足月胎膜早破患者的疗效分析

Effect Analysis of Ritodrine Hydrochloride Combined with Transabdominal Amniotic Cavity Perfusion in Patients with Preterm Premature Rupture of Membranes

目的探讨盐酸利托君联合经腹羊膜腔灌注术对未足月胎膜早破患者的疗效。方法选取2020年6月—2023年9月费县人民医院收治的86例未足月胎膜早破患者为研究对象,按照随机数字表法将其分为对照组与观察组,每组43例。对照组采用经腹羊膜腔灌注术和乳酸菌阴道胶囊治疗,观察组在对照组基础上加用盐酸利托君治疗。对比两组患者的血清炎症因子、临床相关指标、母婴结局及不良反应发生情况。结果治疗后,两组肿瘤坏死因子-α、白细胞介素-6、血清淀粉样蛋白A水平均较治疗前降低,且观察组均低于对照组,差异有统计学意义(P<0.05)。观察组孕周延长时间长于对照组,宫缩抑制及持续治疗时间均短于对照组,组间差异有统计学意义(P<0.05)。观察组母体不良妊娠结局发生率、围产儿不良妊娠结局发生率分别为4.65%、2.33%,均低于对照组的23.26%、18.60%,组间差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论盐酸利托君与经腹羊膜腔灌注术共同应用于未足月胎膜早破患者,能有效缓解炎症症状,改善临床相关指标及母婴结局,并且具有良好的安全性。

Objective To investigate the efficacy of ritodrine hydrochloride combined with transabdominal amniotic cavity perfusion in the treatment of preterm premature rupture of membrane.Methods A total of 86 patients with premature rupture of membrane admitted to Feixian County People's Hospital from June 2020 to September 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 43 cases in each group.The control group was treated with transabdominal amniotic cavity perfusion and lactobacillus vaginal capsule,and the observation group was treated with ritodrine hydrochloride on the basis of the control group.Serum inflammatory factors,clinical related indicators,maternal and infant outcomes and adverse reactions were compared between the two groups.Results After treatment,the levels of tumor necrosis factor-αinterleukin-6 and serum amyloid A in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the difference were statistically significant(P<0.05).The prolongation time of gestation in observation group was longer than that in the control group,and the contraction inhibition and duration of treatment were shorter than those in the control group,and the differences between the groups were statistical significance(P<0.05).The incidence of maternal adverse pregnancy outcomes and perinatal adverse pregnancy outcomes in the observation group were 4.65%and 2.33%,respectively,which were lower than 23.26%and 18.60%in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined application of ritodrine hydrochloride and transabdominal amniotic carity perfusion in patients with preterm premature rupture of membranes can effectively relieve inflammatory symptoms,improve clinical indicators and maternal and infant outcomes,and has good safety.