铜死亡在血液系统肿瘤中的研究进展

The advancement of cuproptosis in hematological tumors

铜死亡是一组不同于调亡、坏死性调亡和铁死亡的独立死亡形式,由铜所介导,主要影响线粒体三羧酸(TCA)循环中蛋白酶硫辛酰化并通过寡聚表现出细胞毒性,但其具体机制、信号转导过程和调控的方式仍然不清楚。线粒体在铜死亡发生发展中处于中心地位,影响细胞对铜毒性的敏感性。近年来,血液系统肿瘤通过靶向治疗与免疫治疗取得了较好的缓解,但仍存在复发率较高及预后较差的问题,因此需找到更加完善的预后指标以及开辟新的治疗思路。本文总结了铜与线粒体在肿瘤发生发展中的交互作用,为进一步探究铜死亡的机制以及应对血液系统肿瘤提供思路。

Cuproptosis is a type of independent cell death form,that differs from apoptosis,necroptosis and ferroptosis.It is mediated by Copper(Cu),and mainly affects the lipoylation of proteases in the mitochondrial tricarboxylic acid(TCA)cycle and exhibits cytotoxicity through oligomerization;however,its specific mechanism,signal transduction process and regulation mode are still not clear.Mitochondria affect the sensitivity of cells to copper toxicity and play a central role in the occurrence and development of copper-related death.In recent years,though hematological tumors have achieved better remission through targeted therapy and immunotherapy,they are associated with high recurrence rates and poor prognoses.It is therefore imperative to find better prognostic indicators and new treatment ideas.This paper summarizes the interaction between Cu and mitochondria in the development of tumors and provides ideas for further exploration of the mechanism of copper death and coping with hematological tumors.