子痫前期患者孕早期和孕中期血清学及超声指标情况与血压的相关性

Serological and ultrasound indicators and their correlation with blood pressure in patients with preeclampsia in early and middle stage of pregnancy

目的 探讨子痫前期(PE)患者孕早期和孕中期血清学及超声指标情况及与血压的相关性。方法 选取2018年9月至2022月7月广东佛山顺德新容奇医院(本院)收治的PE患者542例作为研究组,选取同期来本院行常规产检的458名健康孕妇作为对照组。收集两组在孕早期(妊娠10~13周)、孕中期(妊娠14~27周)的维生素A、维生素E、血小板(PLT)、子宫动脉阻力指数(RI)、搏动指数(PI)(左侧命名为RI1、PI1,右侧命名为RI2、PI2)。结果 研究组孕早期及孕中期维生素E水平、RI1、PI1、RI2、PI2水平高于对照组,差异有统计学意义(P <0.05);研究组孕早期及孕中期PLT水平低于对照组,差异有统计学意义(P <0.05)。研究组孕中期维生素E水平、RI1、PI1、RI2、PI2水平高于孕早期,差异有统计学意义(P <0.05);研究组孕中期PLT水平低于孕早期,差异有统计学意义(P <0.05)。研究组孕早期及孕中期的维生素E水平、RI1、PI1、RI2、PI2水平与血压水平之间呈正相关,PLT水平与血压水平呈负相关(P <0.05)。结论 维生素E、PLT、RI、PI水平可以有效预测PE的发生,维生素E、RI、PI水平与PE患者的血压水平之间呈正相关,PLT与患者血压水平呈负相关。

Objective To investigate serological and ultrasound indicators and their correlation with blood pressure in patients with preeclampsia(PE)in early and middle stage of pregnancy.Methods A total of 542 patients with PE admitted to Shunde New Rongqi Hospital of Foshan City in Guangdong Province(our hospital)from September 2018 to July 2022 were selected as the study group.458 healthy pregnant women who came to our hospital for routine obstetric examination during the same period were selected as the control group.Vitamin A,vitamin E,platelet(PLT),resistance index of uterine artery(RI),and pulsatility index(PI)(named RI1 and PI1 on the left side,and RI2 and PI2 on the right side)were collected from the two groups in the early and(10 to 13 weeks of gestation)and middle(14 to 27 weeks of gestation)stage of pregnancy.Results Levels of vitamin E,RI1,PI1,RI2 and PI2 in early and middle stage of pregnancy were higher in the study group than those in the control group,with statistically significant differences(P<0.05).PLT level in early and middle stage of pregnancy was lower in the study group than that in the control group,with a statistically significant difference(P<0.05).Levels of vitamin E,RI1,PI1,RI2 and PI2 were higher in the middle stage of pregnancy than those in the early stage of pregnancy in the study group,with statistically significant differences(P<0.05).PLT level was lower in the middle stage of pregnancy than that in the early stage of pregnancy in the study group,with a statistically significant difference(P<0.05).In early and middle stage of pregnancy,there was a positive correlation between levels of vitamin E,RI1,PI1,RI2,and PI2 and the blood pressure level,with a negative correlation between PLT level and the blood pressure level in the study group(P<0.05).Conclusion The levels of vitamin E,PLT,RI and PI can effectively predict the occurrence of PE.The levels of vitamin E,RI and PI are positively correlated with the blood pressure of PE patients,while the levels of PLT are negatively correlated with the blood pressure of PE patients.