奥曲肽联合泮托拉唑在急性非静脉曲张性上消化道出血治疗中的疗效

Efficacy of Octreotide Combined with Pantoprazole in the Treatment of Acute Non-varicose Upper Gastrointestinal Bleeding

目的 探讨奥曲肽与泮托拉唑共同治疗急性非静脉曲张性上消化道出血的临床效果。方法 非随机选取2020年8月—2023年8月上海蓝十字脑科医院内科110例急性非静脉曲张性上消化道出血患者作为研究对象,根据治疗方式不同分为两组,每组55例。对照组采用泮托拉唑治疗,研究组采用奥曲肽联合泮托拉唑治疗,分析两组的治疗效果、血浆纤维蛋白、D-二聚体、血红蛋白、红细胞指标、再出血率、住院时间、胃液pH、止血时间及不良反应。结果 研究组胃液pH大于对照组,再出血率、住院时间、止血时间均小于对照组,差异有统计学意义(P均<0.05);研究组治疗后的血浆纤维蛋白、D-二聚体均低于对照组,血红蛋白、红细胞水平均高于对照组,差异有统计学意义(P均<0.05);研究组的治疗效果94.55%(52/55)与对照组83.64%(46/55)相比更优,差异有统计学意义(χ^(2)=4.975,P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论 急性非静脉曲张性上消化道出血施以奥曲肽与合泮托拉唑共同治疗,可以有效降低机体的临床再出血风险,提高止血效果,且不良反应的临床发生风险较小,加速患者身体康复,缩短止血时间、住院时间,值得临床借鉴。

Objective To investigate the clinical effect of octreotide and Pantoprazole in the treatment of acute non-varicose upper gastrointestinal bleeding.Methods A total of one hundred and ten patients with acute non-varicose up-per digestive tract hemorrhage from the Internal Medicine Department of Shanghai Blue Cross Brain Hospital from Au-gust 2020 to August 2023 were non-randomly selected as the research objects,and divided into two groups according to different treatment methods,fifty-five cases in each group.Pantoprazole was treated for the control group,and oc-treotide combined with Pantoprazole was treated for the study group.The therapeutic effect,plasma fibrin,D-dimer,hemoglobin,red blood cell index,rebleeding rate,length of hospital stay,pH of gastric fluid,hemostatic time and ad-verse reactions of the two groups were analyzed.Results The pH of gastric fluid in the study group was higher than that in the control group,and the rebleeding rate,hospital stay and hemostatic time were lower than those in the con-trol group,the differences were statistically significant(all P<0.05).After treatment,plasma fibrin and D-dimer levels in study group were lower than those in the control group,hemoglobin and erythrocyte levels were higher than those in the control group,the differences were statistically significant(all P<0.05).Compared with the control group 83.64%(46/55),the treatment effect of the study group 94.55%(52/55)was better,the differencs was statistically significant(χ^(2)=4.975,P<0.05).There was no statistically significant difference in the incidence between the two groups(P>0.05).Conclusion The combined treatment of octreotide and Pantoprazole for acute non-varicose upper gastrointestinal hem-orrhage can effectively reduce the risk of clinical rebleeding and improve the hemostatic effect,and the clinical risk of adverse reactions is small,accelerate the physical recovery of patients,shorten the time of hemostasis and hospital stay,which is worthy of clincal reference.