布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿哮喘急性发作的效果分析

Effect Analysis of Budesonide Combined With Salbutamol Sulfate Aerosol Inhalation in the Treatment of Acute Asthma Attack in Children

目的 探究布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿哮喘急性发作的效果。方法 非随机选取2022年5月—2023年5月赤峰市医院收治的108例小儿哮喘急性发作患儿为研究对象,根据治疗方法不同分成对照组与观察组,每组54例。对照组通过硫酸沙丁胺醇雾化吸入治疗,观察组通过布地奈德与沙丁胺醇雾化吸入联合治疗,比较两组治疗效果、不良反应发生率、肺功能、临床症状消失时间及炎症因子水平。结果观察组治疗总有效率为98.15%(53/54),高于对照组的85.19%(46/54),差异有统计学意义(χ^(2)=4.364,P<0.05);观察组不良反应发生率略低于对照组,但差异无统计学意义(P>0.05);观察组治疗后肺功能优于对照组,差异有统计学意义(P均<0.05);观察组各项临床症状消失时间均少于对照组,差异有统计学意义(P均<0.05);治疗后观察组炎症因子水平低于对照组,差异有统计学意义(P均<0.05)。结论 布地奈德与硫酸沙丁胺醇共同用药治疗,可对小儿哮喘急性发作患儿发挥重要治疗作用,疗效好,治疗安全性高,促进患儿肺功能指标恢复,减少临床症状消失时间,减轻炎症反应,对患儿尽早康复有积极影响。

Objective To explore the effect of budesonide combined with salbutamol sulfate aerosol inhalation in the treatment of acute asthma attack in children.Methods A total of 108 children with acute asthma attack treated in Chi-feng Hospital from May 2022 to May 2023 were non-randomly selected as the study objects and divided into control group and observation group according to different treatment methods,with 54 cases in each group.The control group was treated with aerosol inhalation of salbutamol sulfate,and the observation group was treated with combined aerosol inhalation of budesonide and salbutamol.The therapeutic effect,incidence of adverse reactions,lung function,disap-pearance time of clinical symptoms and levels of inflammatory factors were compared between the two groups.Results The total effective rate of the observation group was 98.15%(53/54),higher than 85.19%(46/54)of the control group,the difference was statistically significant(χ^(2)=4.364,P<0.05).The incidence of adverse reactions in observation group was slightly lower than that in control group,but the difference was not statistically significant(P>0.05).After treat-ment,the lung function of observation group was better than that of control group,and the difference were statistically significant(all P<0.05).The disappearance time of clinical symptoms in the observation group was less than that in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of inflamma-tory factors in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The combined treatment of budesonide and salbutamol sulfate can play an impor-tant role in the treatment of children with acute asthma attack,with good efficacy and high treatment safety,promote the recovery of pulmonary function indicators in children,reduce the time for clinical symptoms to disappear,reduce inflammation,and have a positive impact on the early recovery of children.