糖萼与动脉粥样硬化的研究进展

Progress in the glycocalyx and atherosclerosis

动脉粥样硬化(As)是心脑血管疾病中最常见的病变,血管内皮功能障碍是As的初始阶段,糖萼(GCX)作为血管内皮表面覆盖的物理屏障,可通过调节血管通透性、舒张功能、细胞间通讯及炎症细胞黏附等,参与As的发生发展。因此,保持血管内皮GCX完整性可能是As治疗的潜在靶点。此外,GCX脱落水平可反映As严重程度。因此,GCX降解产物水平(如硫酸乙酰肝素、透明质酸等)可能用于评估As的严重程度。本文就GCX在As发生中的研究进展进行综述。

Atherosclerosis is the most common disease in cardiovascular and cerebrovascular diseases,and vascular endothelial dysfunction is the initial stage of atherosclerosis.As a physical barrier between the flowing blood and the en-dothelium,glycocalyx can participate in the occurrence and development of atherosclerosis by regulating vascular permeabili-ty,diastolic function,intercellular communication and inflammatory cell adhesion.Therefore,the maintenance or restora-tion of the integrity of the glycocalyx may be a potential therapeutic target for atherosclerosis.Moreover,the abscission level of glycocalyx can reflect the severity of atherosclerosis.Therefore,the level of glycocalyx degradation products(such as acetheparan sulfate,hyaluronic acid,etc)may be used to evaluate the severity of atherosclerosis in the future.This review summarizes the research progress of glycocalyx in atherogenesis.