真武汤联合丹参饮对慢性心力衰竭患者的临床疗效

Clinical effects of Zhenwu Decoction combined with Danshen Drink on patients with chronic heart failure

目的探讨真武汤联合丹参饮对慢性心力衰竭患者的临床疗效。方法86例患者随机分为对照组和观察组,每组43例,对照组给予常规治疗,观察组在对照组基础上加用真武汤联合丹参饮,疗程4周。检测心功能指标(LVFS、LVEDD、LVEF)、血清指标(hs-cTnI、sST2、NT-proBNP、MMP-9)、炎症因子(IL-6、TNF-α、hs-CRP)、血小板聚集率、QTcd、不良反应发生率变化。结果治疗后,2组LVFS、LVEF升高(P<0.05),LVEDD、血清指标、炎症因子、血小板聚集率、QTcd降低(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论真武汤联合丹参饮可安全有效地改善慢性心力衰竭患者hs-cTnI水平和血小板聚集功能。

AIM To explore the clinical effects of Zhenwu Decoction combined with Danshen Drink on patients with chronic heart failure.METHODS Eighty-six patients were randomly assigned into control group(43 cases)for 4-week intervention of conventional treatment,and observation group(43 cases)for 4-week intervention of Zhenwu Decoction,Danshen Drink and conventional treatment.The changes in cardiac function indices(LVFS,LVEDD,LVEF),serum indices(hs-cTnI,sST2,NT-proBNP,MMP-9),inflammatory factors(IL-6,TNF-α,hs-CRP),platelet aggregation rate,QTcd and incidence of adverse reactions were detected.RESULTS After the treatment,the two groups demonstrated increased LVFS,LVEF(P<0.05),and decreased LVEDD,serum indices,inflammatory factors,platelet aggregation rate,QTcd(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with chronic heart failure,Zhenwu Decoction combined with Danshen Drink can safely and effectively improve hs-cTnI level and platelet aggregation functions.