盐酸氨溴索联合头孢曲松钠治疗老年慢性支气管炎急性发作的临床效果

Clinical Effect of Ambroxol Hydrochloride Combined with Ceftriaxone Sodium in Treating Acute Exacerbation of Chronic Bronchitis in Elderly People

目的:探究盐酸氨溴索联合头孢曲松钠在老年慢性支气管炎(CB)急性发作患者中的应用价值。方法:将2020年3月—2022年3月湛江市徐闻县人民医院收治的200例老年CB急性发作患者随机分为对照组(n=100)和观察组(n=100)。对照组采用头孢曲松钠治疗,观察组采用头孢曲松钠联合盐酸氨溴索治疗。对比两组临床疗效、症状消失时间、排痰量、炎性因子水平、不良反应发生率。结果:观察组治疗总有效率高于对照组(P=0.002);观察组喘息、肺啰音、咳嗽症状消失时间短于对照组,排痰量多于对照组(P<0.001);两组治疗后白细胞介素-8、C反应蛋白、肿瘤坏死因子-α水平降低,观察组低于对照组(P<0.05);对照组不良反应发生率为4.00%,观察组为5.00%,差异无统计学意义(P>0.05)。结论:头孢曲松钠联合盐酸氨溴索治疗老年CB急性发作的效果较好,可缩短患者症状消失时间,提高排痰量,降低炎性因子水平,用药安全性较高。

Objective:To investigate the application value of ambroxol hydrochloride combined with ceftriaxone sodium in elderly patients with acute attack of chronic bronchitis(CB).Methods:Two hundred cases of elderly patients with acute exacerbation of CB admitted to Zhanjiang Xuwen County People's Hospital from March 2020 to March 2022 were randomly divided into the control group(n=100)and the observation group(n=100).The control group received ceftriaxone sodium treatment,and the observation group received ceftriaxone sodium and ambroxol hydrochloride treatment.Compared the clinical efficacy,symptom disappearance time,sputum volume,inflammatory factor level,and the incidence of adverse reactions of the both groups.Results:Compared with the control group,the overall treatment efficacy rate in the observation group was higher(P=0.002);compared with the control group,the disappearance time of wheezing,pulmonary rales,and cough symptoms in the observation group was shorter,and the amount of sputum expectoration was more(P<0.001);after treatment,the levels of interleukin-8,C-reactive protein,and tumor necrosis factor-αof the two groups were lower than those before treatment,and the observation group was lower than that in the control group(P<0.05);the incidence of adverse reactions was 4.00%in the control group and 5.00%in the observation group,and the difference was not statistically significant(P>0.05).Conclusion:Ceftriaxone sodium combined with ambroxol hydrochloride is more effective in treating acute exacerbation of CB in the elderly,which can shorten the time of symptom disappearance of the patients,improve the amount of sputum,reduce the level of inflammatory factors,and the safety of medication is higher.