抗甲状腺药物导致粒细胞缺乏研究进展

Research progress on agranulocytosis caused by antithyroid drugs

在我国,抗甲状腺药物是治疗甲状腺功能亢进症的首选治疗手段,然而不良反应为粒细胞缺乏症,该病起病隐匿,一经发现需要紧急处理。目前国内外对于抗甲状腺药物导致粒细胞缺乏症机制尚不明确,本文从药物的直接毒性作用、免疫作用、基因易感性等方面进行综述,以期为临床提供更优的治疗方案和预后。

In China,antithyroid drugs are the first choice of treatment for hyperthyroidism.However,their side effects may result in agranulocytosis,which has an insidious onset and requires urgent treatment.Up to date,the mechanisms of agranulocytosis caused by antithyroid drugs is still unclear.Herein,the article reviewed the direct toxic activities,the immune effects,and the genetic susceptibility of antithyroid drugs,which may be helpful to provide better clinical treatment options and improve the prognosis of agranulocytosis caused by the drugs.