妊娠期甲状腺功能亢进症对后代神经精神发育的影响

Impact of maternal hyperthyroidism during pregnancy on neurological and psychiatric development of offspring

妊娠期甲状腺功能亢进症(简称甲亢)可对母亲和胎儿健康产生不良影响,但其对后代神经精神发育影响的报道较少。本文从妊娠期甲亢对后代脑的形态、智商和神经精神障碍等多方面的影响进行文献综述,发现妊娠期甲亢可能与后代脑容量减少、皮质和灰质体积下降、智商降低以及抑郁症风险增加相关,但与后代其他神经精神障碍的关系尚不明确,因此未来仍需进一步研究探讨。

Gestational hyperthyroidism can significantly increase health risks to both mother and fetal.However,there are few reports on its impact on the neuropsychological development of offspring.This article reviews the literature related to the effect of hyperthyroidism during pregnancy on brain structure,intelligence quotient(IQ)and neuropsychiatric disorders of offsprings.It was found that hyperthyroidism during pregnancy may be associated with reduced brain volume and cortical gray matter volume,lower IQ,and increase the risk of depression in offspring.However,its’relationship with other mental and emotional well-being disorder of the offspring is unclear.