胰腺脂肪沉积与动脉粥样硬化的关联研究进展

Research progress of the association between intra⁃pancreatic fat deposition and atherosclerosis

胰腺脂肪沉积(intrapancreatic fat deposition,IPFD)是我国最常见的胰腺疾病。近年来越来越多的证据表明IPFD与动脉粥样硬化密切相关,也有部分研究不支持两者的相关性,这可能受到研究人群、动脉粥样硬化检测方法和IPFD诊断标准不同的影响。因此,亟需大样本前瞻性研究进一步明确两者之间的联系。两者相关性涉及的机制可能与炎症、氧化应激、低脂联素血症以及糖代谢等有关。目前IPFD无特异性治疗方法,减肥已被证明可显著减少胰腺沉积的脂肪含量。临床上除关注IPFD本身的治疗外,还应重视对IPFD患者心血管疾病发病风险的评估,以便早干预、早诊治。

Intra⁃pancreatic fat deposition(IPFD)is the most common disease of pancreas in our country.In recent years,there has been increasing evidence that IPFD is closely related to atherosclerosis.However,some studies do not support the correlation between them,which may be affected by differences in study population,atherosclerosis detection methods,and IPFD diagnostic criteria.Therefore,large⁃sample prospective studies are urgently needed to further clarify the correlation between IPFD and atherosclerosis.The mechanisms involved in correlation between them may be related to inflammation,oxidative stress,hypoadiponectinemia and glucose metabolism.There is currently no specific treatment for IPFD,while weight loss has been shown to significantly reduce the amount of fat deposited in the pancreas.In addition to the treatment of IPFD itself,clinicians should also pay attention to the assessment of the risk of cardiovascular disease in IPFD patients to facilitate early diagnosis and early intervention.