子宫内膜异位症患者的CYFRA21-1、CA19-9与CA125表达变化及诊断价值分析

Expressions and diagnostic values of CYFRA21-1,CA19-9 and CA125 in patients with endometriosis

目的探究细胞角蛋白19片段抗原(CYFRA21-1)、糖链抗原19-9(CA19-9)与糖链抗原125(CA125)在子宫内膜异位症(EM)中的表达水平变化及诊断效能。方法选取100例EM患者纳入病例组,100例同期健康体检者纳入健康组,比较病例组、健康组的CYFRA21-1、CA19-9与CA125表达水平,绘制受试者工作特征(ROC)曲线分析CYFRA21-1、CA19-9与CA125诊断EM的预测价值,并采用Pearson相关系数分析CYFRA21-1、CA19-9与CA125水平与EM患者美国生殖医学协会子宫内膜异位症分期(r-AFS)评分的相关性。结果病例组的CYFRA21-1、CA19-9与CA125表达水平均高于健康组,差异均有统计学意义(t分别=15.48、10.45、14.79,P均<0.05)。中重度组患者的CYFRA21-1、CA19-9与CA125表达水平均明显高于轻度组,差异均有统计学意义(t分别=-7.64、-17.96、-11.29,P均<0.05)。CYFRA21-1、CA19-9与CA125诊断EM的曲线下面积(AUC)分别为0.92、0.82、0.92。EM患者CYFRA21-1、CA19-9与CA125水平与r-AFS评分均呈正相关(r分别=0.68、0.77、0.64,P均<0.05)。结论CYFRA21-1、CA19-9与CA125在EM患者异常高表达,可作为敏感预测指标,并且与EM病情密切相关,可作为病情评估的可靠指标。

Objective To investigate the expression changes and diagnostic efficacy of cytokeratin 19 fragment antigen(CYFRA21-1),glycan antigen 19-9(CA19-9),and glycan antigen 125(CA125)in endometriosis(EM).Methods To⁃tally 100 patients with EM were selected as the case group,and 100 healthy individuals who underwent physical examina⁃tions during the same period were included in the health group.The expression levels of CYFRA21-1,CA19-9,and CA125 were compared between the case group and the health group.Receiver operating(ROC)characteristic curves were drawn to analyze the predictive value of CYFRA21-1,CA19-9,and CA125 in diagnosing EM.Pearson correlation coefficients were used to analyze the correlation between CYFRA21-1,CA19-9,and CA125 levels and the r-AFS score of EM patients.Results The expression levels of CYFRA21-1,CA19-9,and CA125 in the case group were higher than those in the healthy group,and the differences were statistically significant(t=15.48,10.45,14.79,P<0.05).The expression levels of CYFRA21-1,CA19-9,and CA125 in the moderate to severe group were significantly higher than those in the mild group,and the differences were statistically significant(t=-7.64,-17.96,-11.29,P<0.05).The AUC for diagnosing EM in CY⁃FRA21-1,CA19-9,and CA125 were 0.92,0.82,and 0.92,respectively.The levels of CYFRA21-1,CA19-9,and CA125 in EM patients were positively correlated with r-AFS scores(r=0.68,0.77,0.64,P<0.05).Conclusion CYFRA21-1,CA19-9,and CA125 are abnormally overexpressed in EM patients and can be used as sensitive predictive indicators.They are closely related to the severity of EM and can serve as reliable indicators for disease assessment.