疏风宣肺汤联合穴位埋线对风燥犯肺型咳嗽变异性哮喘患者肺功能及炎症指标的影响

Effect of Shufeng Xuanfei Decoction Combined with Acupoint Catgut Embedding on Lung Function and Inflammatory Markers in Patients with Wind-Dryness Invading the Lung Type Variant Asthma

目的:探究疏风宣肺汤联合穴位埋线对风燥犯肺型咳嗽变异性哮喘(CVA)患者气道炎症、肺部功能及免疫平衡的影响。方法:选择符合纳入标准的风燥犯肺型CVA患者120例,依据随机数字表随机分为对照组和观察组,每组各60例。对照组采用孟鲁司特钠联合布地奈德/福莫特罗治疗,观察组在对照组治疗基础上采用疏风宣肺汤联合穴位埋线治疗,两组均连续治疗30 d。比较两组患者治疗前后咳嗽相关指标(咳嗽症状积分、LCQ评分)、肺功能指标(FVC、FEV_(1)、PEF)、气道高反应性指标(LgE、EOS、FeNO)、炎症因子(hs-CRP、IL-4、TNF-α)、免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))等相关指标的变化情况,并比较临床疗效、不良反应及复发情况。结果:与治疗前比较,两组患者治疗后咳嗽症状积分,血清hs-CRP、IL-4及TNF-α水平,IgE、EOS、FeNO水平以及CD8^(+)均明显降低(P<0.05);LCQ评分,FVC、FEV_(1)、PEF水平以及CD4^(+)、CD4^(+)/CD8^(+)均明显升高(P<0.05)。治疗后两组比较,观察组上述指标较对照组改善明显(P<0.05)。观察组临床总有效率93.33%(56/60),明显高于对照组临床总有效率78.33%(47/60)(P<0.05)。观察组咳嗽时间明显缩短,随访期间复发率明显降低(P<0.05)。观察组不良反应发生率11.67%(7/60),与对照组不良反应发生率16.67%(10/60)比较,差异无统计学意义(P>0.05)。结论:疏风宣肺汤联合穴位埋线可提高风燥犯肺型CVA患者治疗效果,减轻气道炎症反应,改善肺部功能,并促进免疫平衡。

Objective:To explore the effects of Shufeng Xuanfei Decoction combined with acupoint catgut embedding on airway inflammation,lung function,and immune balance in patients with cough variant asthma(CVA)of the wind-dryness invading the lung type.Methods:A total of 120 patients with wind-dryness invading the lung type CVA who met the inclusion criteria were randomly divided into a control group and an observation group,with 60 cases in each group.The control group was treated with montelukast sodium combined with budesonide/formoterol,while the observation group received the same plus Shufeng Xuanfei Decoction combined with acupoint catgut embedding.Both groups were treated for 30 days.Cough-related indicators(cough symptom score,LCQ score),lung function indicators(FVC,FEV_(1),PEF),airway hyperresponsiveness indicators(IgE,EOS,FeNO),inflammatory factors(hs-CRP,IL-4,TNF-α),and immune function indicators(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))were compared before and after treatment in both groups.Clinical efficacy,adverse reactions,and recurrence rates were also compared.Results:After treatment,compared to baseline,both groups showed significant reductions in cough symptom score,serum hs-CRP,IL-4,TNF-αlevels,IgE,EOS,FeNO levels,and CD8^(+)(P<0.05);LCQ score,FVC,FEV_(1),PEF levels,CD4^(+),and CD4^(+)/CD8^(+)significantly increased(P<0.05).Posttreatment,the observation group showed significantly greater improvement in the aforementioned indicators compared to the control group(P<0.05).The overall clinical effective rate in the observation group was 93.33%(56/60),significantly higher than 78.33%(47/60)in the control group(P<0.05).The observation group had a significantly shorter cough duration and a significantly lower recurrence rate during follow-up(P<0.05).The incidence of adverse reactions was 11.67%(7/60)in the observation group and 16.67%(10/60)in the control group,with no statistically significant difference(P>0.05).Conclusion:Shufeng Xuanfei Decoction combined with acupoint catgut embedding can enhance the therapeutic effect in patients with wind-dryness invading the lung type CVA,reduce airway inflammation,improve lung function,and promote immune balance.