非酒精性脂肪肝病是心血管疾病危险因素

Nonalcoholic fatty liver disease is a risk factor for cardiovascular disease

非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)是一种以肝内脂肪过度沉积为特征的慢性进行性肝病,影响全球约四分之一的人口.流行病学研究表明,25%~40%的NAFLD合并心血管疾病(cardiovascular disease,CVD),并且CVD是此类患者的主要死因之一,但尚未引起充分重视.全面了解NAFLD与CVD的关系对于改善患者的临床预后和生存至关重要.本文将系统性综述NAFLD与CVD危险因素的相关性及NAFLD综合干预对CVD风险的影响,有助于临床医生早期识别NAFLD患者发生CVD的风险,并采取防治措施,从而改善心血管不良预后.

Nonalcoholic fatty liver disease(NAFLD)is a chronic progressive liver disease characterized by excessive intrahepatic fat deposition,affecting about a quarter of the global population.Epidemiological studies have shown that 25%of NAFLD patients have cardiovascular disease(CVD),and CVD is one of the leading causes of death in these subjects,but it has not attracted enough attention.A comprehensive understanding of the association between NAFLD and CVD is critical important to improve the clinical prognosis and survival of patients.In this review,we systemically review the relationship between NAFLD and CVD risk factors and the effect of comprehensive intervention of NAFLD on the risk of CVD,which is beneficial for clinicians to identify the risk of CVD in patients with NAFLD early and adopt preventive measures to improve the poor cardiovascular prognosis.