核酸不对称催化研究进展

Research progress of nucleic acids based asymmetric catalysis

核酸催化化学是以核酸催化性能及应用研究为主题的催化化学和生命科学交叉前沿领域.近年,核酸作为生物骨架与金属物种通过特定结合方式组装成核酸杂化催化剂,催化了一系列重要的水相不对称反应,实现了将核酸的手性成功转移到不对称反应产物中.本文系统总结了近年来基于DNA、RNA和核苷酸构筑核酸杂化催化剂的不对称催化研究进展,重点分析了核酸杂化催化剂的构筑策略、调控方法以及不对称催化构效关系方面的研究结果,最后对核酸催化化学的未来发展方向及其潜在应用进行了展望.

Nucleic acid catalytic chemistry is an advanced interdisciplinary field of catalytic chemistry and life science with the core research on the catalytic properties of nucleic acids.In recent years,nucleic acid hybrid catalysts have been constructed through incorporation of metal species into the biological scaffolds of nucleic acids with specific binding modes.These catalysts have achieved a series of valuable aqueous-phase asymmetric transformations and realized the chirality transfer from nucleic acids to enantiomeric products.In this review,we summary the recent progress of nucleic acids-based enantioselective catalysis using DNA,RNA and nucleotides as chiral scaffolds.In particular,we mainly analyze the research results of design strategies,tuning methods and structure-activity relationship of nucleic acids hybrid catalysts.Finally,we outlook the future directions and potential applications of nucleic acids catalytic chemistry.