老年男性2型糖尿病患者肌少症与体脂含量相关性的研究

Correlation between sarcopenia and body fat percentage in elderly male with type 2 diabetes mellitus

目的 探讨老年男性T2DM患者肌少症与体脂含量(BF%)的相关性.方法 选取2018年12月至2019年9月于首都医科大学宣武医院内分泌科住院治疗的老年男性T2DM患者291例,分为肌少症组(n=35)和非肌少症组(n=256),测定BF%、骨骼肌质量指数(SMI)、握力、步速、HbA1c、血红蛋白(Hb)、血尿酸(SUA)、白蛋白及维生素D(Vit D).结果 与非肌少症组比较,肌少症组年龄、HbA1c、BF%升高,BMI、Vit D、SMI、Hb、SUA、ALB、握力、步速降低(P<0.05或P<0.01).Pearson相关分析显示,SMI与BMI、VitD、Hb、SUA呈正相关(P<0.05或P<0.01),与HbA1c呈负相关(P<0.01);握力、步速与VitD、Hb呈正相关(P<0.01),与BF%呈负相关(P<0.01).Logistic回归分析显示,年龄、BF%是肌少症的危险因素,BMI、Vit D是肌少症的保护因素.结论 高BF%显著增加老年男性T2DM患者肌少症风险.

Objective To explore the correlation between sarcopenia and body fat percentage(BF%)in elderly male patients with type 2 diabetes mellitus(T2DM).Methods A total of 291 elderly male T2DM patients who were hospitalized in the Endocrinology Department of Xuanwu Hospital,Capital Medical University were enrolled in this study from December 2018 to September 2019.All the patients were divided into sarcopenia group(n=35)and non sarcopenia group(n=256).BF%,skeletal muscle mass index(SMI),grip strength,gait speed,HbA1c,hemoglobin(Hb),blood uric acid(SUA),albumin and vitamin D(Vit D)were measured in all the participants.Results Compared with the non sarcopenia group,age,HbA1c and BF%were increased,while BMI,Vit D,SMI,Hb,SUA,ALB,grip strength,and gait speedwere decreased in sarcopenia group(P<0.05 or P<0.01).Pearson correlation analysis showed that SMI was positively correlated with BMI,Vit D,Hb,and SUA(P<0.05 or P<0.01),and negatively correlated with HbA1c(P<0.01).Grip strength and gait speed are positively correlated with Vit D and Hb(P<0.01),and negatively correlated with BF%(P<0.01).Logistic regression analysis showed that age and BF%were risk factors for sarcopenia,while BMI and Vit D were protective factors for sarcopenia.Conclusions High BF%significantly increases the risk of sarcopenia in elderly male T2DM patients.