早期糖代谢异常对青年男性骨骼肌含量影响的研究

Effect of early glucose metabolism abnormality on skeletal muscle content of young men

目的 探讨早期糖代谢异常对青年男性骨骼肌含量的影响.方法 选取2020 年9 月至 2021 年 9 月于我院体检中心体检的男性 88 例,根据FPG、2 hPG水平分为血糖正常组(NGT,n=47)和IGR组(n=41).比较两组FPG、FIns、内脏脂肪面积(VFA)、胰岛素抵抗指数(HOMA-IR)、骨骼肌质量指数(SMI)、体脂率(BFR)等.结果 与NGT组比较,IGR组BMI、WC、FPG、2 hPG、HOMA-IR、VFA升高(P<0.05),HDL-C、SMI降低(P<0.05).Pearson相关分析显示,非DM青年男性SMI与BMI、WC、FPG、2 hPG、HOMA-IR、VFA、BFR呈负相关(P<0.05 或P<0.01).Logistic回归分析显示,BMI是FPG的影响因素,SMI是2 hPG的影响因素.结论 早期糖代谢异常青年男性随着骨骼肌含量减少,餐后血糖升高,FPG主要受BMI影响.

Objective To investigate the effect of early glucose metabolism abnormality on skeletal muscle content of young men.Methods 88 males who underwent physical examinations in our hospital from September 2020 to September 2021 were divided into normal blood glucose group(NGT,n=47)and IGR group(n=41),according to their FPG and 2 hPG levels.FPG,FIns and visceral fat area(VFA)were measured.HOMA‑IR,HOMA‑β,skeletal muscle index(SMI)and body fat ratio(BFR)were calculated.Results Compared with NGT group,the males in IGR group showed elevated BMI,WC,FPG,2 hPG,HOMA‑IR and VFA(P<0.05),but decreased HDL‑C and SMI(P<0.05).Pearson correlation analysis showed that SMI was negatively correlated with BMI,WC,FPG,2 hPG,HOMA‑IR,VFA and BFR in young men(P<0.05 or P<0.01).Logistic regression analysis showed that BMI was the influencing factor of FPG,while SMI was the influencing factor of 2 hPG.Conclusions In young men with abnormal glucose metabolism,the postprandial blood glucose significantly increase with the decrease of skeletal muscle content,and fasting blood glucose is mainly affected by BMI.