硫辛酸诱发的胰岛素自身免疫综合征一例报道

Lipoic acid induced insulin autoimmune syndrome:a case report

胰岛素自身免疫综合征(IAS)是导致低血糖的罕见病因.本文报道1 例57 岁T2DM患者使用硫辛酸后引起反复、无规律、严重低血糖事件,IAA由阴性转阳性,基因检测未检出与受检者临床信息相关的致病性变异及疑似致病性变异,最终确诊为IAS.

Insulin autoimmune syndrome(IAS),also known as autoimmune hypoglycemia,is one of the rare causes of hypoglycemia.Here,we described a case of a 57‑year‑old patient with type 2 diabetes mellitus who experienced recurrent and irregular severe hypoglycemic events after using lipoic acid.His insulin autoantibodies changed from negative to positive,and no pathogenic variation or suspected pathogenic variation related to the clinical feature of the subject was detected by gene test.Eventually,the patient was diagnosed as IAS.