银杏叶片联合氯吡格雷对脑梗死恢复期血液流变学和血清神经细胞因子的影响

Effects of Ginkgo Biloba Leaves Combined with Clopidogrel on Hemorheology and Serum Neurocytokines in Patients with Cerebral Infarction during Recovery Period

目的观察银杏叶片与氯吡格雷联合治疗对脑梗死恢复期患者血液流变学和血清神经细胞因子的影响。方法采用随机数字表法,将江西省中西医结合医院2020年3月至2022年12月期间收治的112例脑梗死恢复期患者分为对照组(n=56,氯吡格雷治疗)和治疗组(n=56,银杏叶片联合氯吡格雷治疗)。对比两组Barthel指数、疗效、美国国立卫生院卒中量表(NIHSS)评分、血液流变学指标、血清神经细胞因子和不良反应。结果治疗组的临床总有效率高于对照组(P<0.05)。与对照组相比,治疗组治疗8周后Barthel指数、脑源性神经营养因子(BDNF)更高,NIHSS评分、神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)和血液流变学指标(全血高切/低切黏度、血细胞比容、血浆黏度)更低(P<0.05)。两组不良反应发生率对比没有显著差异(P>0.05)。结论银杏叶片联合氯吡格雷可以改善脑梗死恢复期患者的神经功能,有效调节血液流变学和血清神经细胞因子水平,提高患者生活自理能力,具有较好的应用价值。

Objective To observe the effects of the combination therapy of ginkgo biloba leaves and clopidogrel on hemorheology and serum neurocytokines in patients with cerebral infarction during recovery period.Methods Using a random number table method,112 patients with cerebral infarction during recovery period who were admitted to Jiangxi Integrated Traditional Chinese and Western Medicine Hospital from March 2020 to December 2022 were divided into a control group(n=56,treated with clopidogrel)and a treatment group(n=56,treated with Ginkgo biloba leaves combined with clopidogrel).The Barthel index,efficacy,National Institutes of Health Stroke Scale(NIHSS)scores,hemorheological indicators,serum neurocytokines,and adverse reactions in two groups were compared.Results The total clinical effective rate of the treatment group was higher than that of the control group(P<0.05).Compared with the control group,Barthel index and brain-derived neurotrophic factor(BDNF)were higher in the treatment group after 8 weeks.NIHSS score,neuron specific enolase(NSE),glial fibrillary acidic protein(GFAP)and hemorheological indexes(whole blood high/low shear viscosity,hematocrit,plasma viscosity)were lower(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgo leaves combined with clopidogrel can improve the neurological function of patients with cerebral infarction,effectively regulate blood rheology and serum nerve cytokines level,improve the self-care ability of patients,and has good application value.