益生菌辅助治疗ICP临床疗效的研究

Study on the Clinical Efficacy of Probiotics in the Adjuvant Treatment of ICP

目的研究益生菌辅助治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效。方法采用随机数表法将我院2022年1月至2023年1月收治的100例ICP患者分为两组,对照组(50例)采用常规药物治疗,研究组(50例)采用常规药物治疗与益生菌辅助治疗,比较两组肝功能指标、炎症因子水平、肠道菌群指标、不良妊娠结局。结果治疗后研究组总胆汁酸(TBA)、血氨(BA)、直接胆红素(DBIL)、总胆红素(TBIL)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、大肠杆菌水平及不良妊娠结局发生率均低于对照组,乳酸杆菌、双歧杆菌水平均高于对照组(P<0.05)。结论益生菌辅助治疗能够有效改善患者肝功能与肠道菌群结构,减少不良妊娠结局发生。

Objective To study the clinical efficacy of probiotics in the treatment of intrahepatic cholestasis of pregnancy(ICP).Methods 100 ICP patients admitted to our hospital from January 2022 to January 2023 were divided into two groups by random number table method.The control group(50 cases)received conventional drug therapy,and the study group(50 cases)received conventional drug therapy and probiotic adjuvant therapy.Liver function indexes,inflammatory factor levels,intestinal flora indexes and adverse pregnancy outcomes were compared between the two groups.Results After treatment,total bile acid(TBA),blood ammonia(BA),direct bilirubin(DBIL),total bilirubin(TBIL),The levels of alanine aminotransferase(ALT),γ-glutamyl transpeptase(γ-GT),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),Eschericiferum and the incidence of adverse pregnancy outcomes were lower than those of control group,while the levels of lactobacillus and bifidobacterium were higher than those of control group(P<0.05).Conclusion Probiotics adjuvant therapy can effectively improve the liver function and intestinal flora structure of patients and reduce adverse pregnancy outcomes.