幽门螺杆菌感染与结直肠息肉相关性因素研究

A Study on the Correlation Factors between Helicobacter Pylori Infection and Colorectal Polyps

目的探讨幽门螺杆菌(HP)感染与结直肠息肉的相关性,并分析HP感染与结直肠癌息肉患者一般特征的关系。方法回顾性分析**医院于2021年8月至2023年8月进行胃肠镜检查以及13C尿素酶呼气试验的205例患者的资料,其中105例为结直肠息肉患者(61例结直肠腺瘤患者),设为病例组(病例组根据HP感染情况分为阳性组60例和阴性组45例)。100例为结直肠无明显异常者,设为对照组。比较两组患者HP感染的情况,并分析HP感染与结直肠癌息肉的相关性。结果病例组的HP感染率为57.14%(60/105),对照组为38.00%(38/100),差异有显著性(P<0.05),且病例组的性别组成、年龄与对照组的差异亦有显著性(P<0.05)。结直肠息肉组中HP阳性组与阴性组在年龄、生长部位、数量、病例类型方面的差异有显著性(P<0.05)。结直肠腺瘤组的HP感染率在不同年龄组的差异有显著性(P<0.05)。多因素Logistic回归分析显示,年龄≥60岁、HP感染、左半结肠是结直肠息肉的独立风险因素,年龄≥60岁、HP感染是腺瘤的独立风险因素(P<0.05)。结论HP感染是结直肠息肉的独立危险因素,对于合并有HP感染的患者而言,年龄越大发生腺瘤性息肉的风险越高,应加强对该部分患者的关注,以早期治疗,预防结直肠癌。

Objective To explore the correlation between Helicobacter pylori(HP)infection and colorectal polyps,and to analyze the relationship between HP infection and the general characteristics of colorectal cancer polyp patients.Methods A retrospective analysis was conducted on the data of 205 patients who underwent gastroscopy and 13C urease breath test in the hospital from August 2021 to August 2023.Among them,105 were patients with colorectal polyps(61 patients with colorectal adenomas)and were divided into a case group(the case group was divided into a positive group of 60 cases and a negative group of 45 cases based on HP infection).100 cases with no obvious abnormalities in the colon and rectum were designated as the control group.Compare the situation of HP infection between two groups of patients and analyze the correlation between HP infection and colorectal cancer polyps.Results The HP infection rate in the case group was 57.14%(60/105),while in the control group it was 38.00%(38/100),with a significant difference(P<0.05).Additionally,there was a significant difference in gender composition and age between the case group and the control group(P<0.05).There were significant differences in age,growth site,quantity,and case type between the HP positive and negative groups in the colorectal polyp group(P<0.05).The HP infection rate in the colorectal adenoma group showed significant differences among different age groups(P<0.05).Multivariate logistic regression analysis showed that age≥60 years,HP infection,and left colon were independent risk factors for colorectal polyps,while age≥60 years and HP infection were independent risk factors for adenomas(P<0.05).Conclusion HP infection is an independent risk factor for colorectal polyps.For patients with concurrent HP infection,the older the age,the higher the risk of developing adenomatous polyps.Therefore,more attention should be paid to this group of patients for early treatment and prevention of colorectal cancer.