中医治疗血管性痴呆作用机制研究进展

Progress in Research on the Mechanism of Traditional Chinese Medicine in Treating Vascular Cementia

血管性痴呆(VaD)是第二常见的痴呆形式,它是一种具有复杂病理生理基础的获得性认知障碍综合征,会导致患者的认知能力和记忆力进行性下降,给家庭及社会造成严重的负担。目前,该病尚无特定的治疗药物,西医治疗疗效欠佳,中医以其安全系数较高、不良反应较少、成本较低、多靶点治疗的优势被广泛用于治疗VaD。研究表明,中医对改善VaD患者的认知功能和生活质量具有显著的作用。本文就近年来对中医治疗VaD的临床疗效和药理机制的研究作一综述。

Vascular dementia(VaD)is the second most common form of dementia.It is an acquired cognitive impairment syndrome with a complex pathophysiological basis.It can lead to a progressive decline in patients'cognitive abilities and memory,causing serious burdens to families and society.At present,there is no specific treatment drug for the disease,and the efficacy of western medicine is poor.Traditional Chinese medicine is widely used to treat VaD because of its advantages of high safety factor,fewer adverse reactions,lower cost,and multitarget treatment.Studies have shown that traditional Chinese medicine has a significant effect on improving cognitive function and quality of life in patients with VaD.This article reviews the recent research on the clinical efficacy and pharmacological mechanism of traditional Chinese medicine in treating VaD.