硫化氢防治胃肠道缺血再灌注损伤的研究现状

Research status of hydrogen sulfide in the prevention and treatment of gastrointestinal ischemia-reperfusion injury

胃肠道缺血再灌注(I/R)损伤是外科创伤患者高发病率和死亡率的主要原因。作为第3种气体信号分子,硫化氢(H_(2)S)在人体胃肠道系统发挥重要的病理生理作用。多种新型H_(2)S供体如ATB-344、AP39对胃肠道I/R损伤具有治疗价值。本文综述了H_(2)S供体对胃肠道I/R损伤保护作用及其作用机制,旨在为胃肠道I/R损伤提供新的治疗方法,以期对其临床用药提供参考。

Gastrointestinal ischemia reperfusion(I/R)injury is a major cause of high morbidity and mortality in patients with surgical trauma.At present,there are few studies on gastrointestinal I/R injury,so it is particularly important to find treatment methods for gastrointestinal I/R injury.As the third gas signaling molecule,H_(2) S plays an important physiological and pathological role in the human gastrointestinal system.Recently,a variety of novel H_(2) S donors such as ATB-344 and AP39 have shown therapeutic value for gastrointestinal I/R injury.Therefore,this article reviewed the treatment of gastrointestinal I/R injury by H_(2) S donors and its mechanism of action,aiming to provide a new treatment method for gastrointestinal I/R injury,in order to provide a reference for clinical medication of gastrointestinal I/R injury.