头孢哌酮钠舒巴坦钠联合阿卡波糖对老年糖尿病合并肺部感染患者免疫功能的影响

Effect of Cefoperazone Sodium and Sulbactam Sodium Combined with Acarbose on Immune Function in Elderly Patients with Diabetes Mellitus Complicated with Pulmonary Infection

目的探究头孢哌酮钠舒巴坦钠联合阿卡波糖在老年糖尿病合并肺部感染患者中的影响。方法回顾性选取2023年1月—2024年4月厦门大学附属第一医院收治的106例糖尿病合并肺部感染患者的临床资料,根据治疗方式不同分两组,各53例。对照组采用头孢哌酮钠舒巴坦钠联合二甲双胍治疗,研究组采用头孢哌酮钠舒巴坦钠联合阿卡波糖治疗。对比两组血糖水平、肺功能、免疫功能、炎症反应。结果治疗后,研究组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组用力肺活量、第1秒用力呼气量、第1秒用力呼气量/用力肺活量水平均高于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组CD3^(+)、CD4^(+)高于对照组,CD8^(+)低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组超敏C反应蛋白、白细胞介素-13、白细胞介素-6、降钙素原水平均低于对照组,差异有统计学意义(P均<0.05)。结论老年糖尿病合并肺部感染患者使用头孢哌酮钠舒巴坦钠联合阿卡波糖治疗,能够降低血糖水平,提高肺功能及免疫功能,降低炎症因子水平。

Objective To explore the effect of cefoperazone sodium and sulbactam sodium combined with acarbose in elderly patients with diabetes mellitus complicated with pulmonary infection.Methods The clinical data of 106 pa⁃tients with diabetes mellitus complicated with pulmonary infection admitted to the First Affiliated Hospital of Xiamen University from January 2023 to April 2024 were retrospectively selected.According to different treatment methods,they were divided into two groups,53 cases in each group.The control group was treated with cefoperazone sodium and sulbactam sodium combined with metformin,and the study group was treated with cefoperazone sodium and sul⁃bactam sodium combined with acarbose.The blood glucose level,lung function,immune function and inflammatory re⁃sponse were compared between the two groups.Results After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of forced vital capacity,forced expiratory volume in the first second,and forced expiratory volume in the first second/forced vital capacity in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,CD3^(+)and CD4^(+)in the study group were higher than those in the control group,and CD8^(+)was lower than that in the control group,the differences were statistically significant(all P<0.05).After treatment,the lev⁃els of high-sensitivity C-reactive protein,interleukin-13,interleukin-6 and procalcitonin in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The use of cefoperazone sodium and sulbactam sodium combined with acarbose in elderly patients with diabetes mellitus complicated with pulmonary infection can reduce blood glucose levels,improve lung function and immune function,and reduce the level of inflammatory factors.