二甲双胍联合维格列汀与利拉鲁肽对肥胖合并2型糖尿病患者的临床疗效对比

Comparison of Clinical Efficacy of Metformin Combined with Vildagliptin and Liraglutide in Obese Patients with Type 2 Diabetes Mellitus

目的比较二甲双胍联合维格列汀与利拉鲁肽对肥胖合并2型糖尿病患者的临床疗效。方法选取2023年1—12月仙游县妇幼保健院收治的108例肥胖合并2型糖尿病患者为研究对象,以治疗方法的不同分为对照组(54例,采用二甲双胍联合维格列汀治疗)和观察组(54例,采用利拉鲁肽治疗)。比较两组血糖、血脂、体重指数、胰岛β细胞功能、不良反应发生率。结果治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组体重指数水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组空腹C肽以及餐后2 h C肽水平均高于对照组,差异有统计学意义(P均<0.05)。结论肥胖合并2型糖尿病患者接受二甲双胍联合维格列汀或利拉鲁肽治疗都能够起到有效的降血糖效果,但是利拉鲁肽的疗效相对更理想。

Objective To compare the clinical efficacy of metformin combined with vildagliptin and liraglutide in obese patients with type 2 diabetes mellitus.Methods A total of 108 obese patients with type 2 diabetes mellitus ad⁃mitted to Xianyou County Maternal and Child Health Hospital from January to December 2023 were selected as the re⁃search objects.According to different treatment methods,they were divided into control group(54 cases,treated with metformin combined with vildagliptin)and observation group(54 cases,treated with liraglutide).The levels of blood glucose,blood lipid,body mass index,isletβcell function and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose and gly⁃cated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of triglyceride,total cholesterol and low density lipopro⁃tein cholesterol in the observation group were lower than those in the control group,and the level of high density lipo⁃protein cholesterol was higher than that in the control group,the differences were statistically significant(all P<0.05).After treatment,and the body mass index level of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of fasting C-peptide and 2-hour postprandial Cpeptide in the observation group were higher than those in the control group,and the differences were statistically sig⁃nificant(both P<0.05).Conclusion Obese patients with type 2 diabetes mellitus receiving metformin combined with vildagliptin or liraglutide treatment can play an effective hypoglycemic effect,but the efficacy of liraglutide is rela⁃tively better.