甘精胰岛素与预混胰岛素分别联合阿卡波糖对2型糖尿病患者血糖控制及胰岛素用量的影响

Effect of Insulin Glargine and Premixed Insulin Combined with Acarbose on Glycemic Control and Insulin Dosage in Patients with Type 2 Diabetes Mellitus

目的探究2型糖尿病(type 2 diabetes mellitus,T2DM)患者采用甘精胰岛素与预混胰岛素分别联合阿卡波糖治疗的效果。方法选取2021年11月—2023年12月仁怀市人民医院收治的112例T2DM患者,按照不同的治疗方法分为两组。对照组(n=56)给予预混胰岛素联合阿卡波糖治疗,观察组(n=56)给予甘精胰岛素联合阿卡波糖治疗,对比两组血糖指标、胰岛功能、胰岛素用量及低血糖发生率。结果治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素均低于对照组,胰岛β细胞功能指数高于对照组,胰岛素用量少于对照组,低血糖发生率低于对照组,差异有统计学意义(P均<0.05)。两组胰岛素抵抗指数比较,差异无统计学意义(P>0.05)。结论甘精胰岛素联合阿卡波糖相较于预混胰岛素联合阿卡波糖治疗效果显著,可减少胰岛素用量,改善T2DM患者血糖及胰岛功能,有效避免低血糖的发生率。

Objective To explore the clinical effect of insulin glargine and premixed insulin combined with acarbose in patients with type 2 diabetes mellitus(T2DM).Methods A total of 112 patients with T2DM admitted to Renhuai People's Hospital from November 2021 to December 2023 were selected and divided into two groups according to dif⁃ferent treatment methods.The control group(n=56)was treated with premixed insulin combined with acarbose,and the observation group(n=56)was treated with insulin glargine combined with acarbose.The blood glucose indexes,is⁃let function,insulin dosage and incidence of hypoglycemia were compared between the two groups.Results After treat⁃ment,the fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c and fasting insulin in the observation group were lower than those in the control group,homeostatic model assessment of isletβcell func⁃tion was higher than that in the control group,the insulin dosage was less than that in the control group,and the inci⁃dence of hypoglycemia was lower than that in the control group,the differences were statistically significant(all P<0.05).There was no statistically significant difference in homeostatic model assessment of insulin resistance between the two groups(P>0.05).Conclusion Compared with premixed insulin combined with acarbose,insulin glargine com⁃bined with acarbose has a significant effect,which can reduce insulin dosage,improve blood glucose and islet function in patients with T2DM,and effectively avoid the incidence of hypoglycemic.