达格列净在治疗2型糖尿病合并充血性心力衰竭中的安全性和有效性研究

Study on the Safety and Efficacy of Dapagliflozin in the Treatment of Type 2 Diabetes Mellitus with Congestive Heart Failure

目的评估达格列净在治疗2型糖尿病合并充血性心力衰竭患者中的安全性和有效性。方法选取2023年4月—2024年3月灌云县中医院收治的70例2型糖尿病合并充血性心力衰竭患者作为研究对象,根据不同的治疗方案分为对照组(n=33)和观察组(n=37)。对照组进行常规治疗,观察组在对照组的基础上进行达格列净治疗。比较两组患者临床治疗效果、血糖水平、心功能相关指标。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。观察组左心室射血分数、心输出量均高于对照组,N端脑钠肽前体低于对照组,差异有统计学意义(P均<0.05)。结论达格列净治疗2型糖尿病合并充血性心力衰竭,可改善患者的血糖水平和心功能,且安全性较高,治疗疗效显著。

Objective To evaluate the safety and efficacy of dapagliflozin in the treatment of patients with type 2 dia⁃betes mellitus complicated with congestive heart failure.Methods A total of 70 patients with type 2 diabetes mellitus complicated with congestive heart failure admitted to Guanyun County Hospital of Traditional Chinese Medicine from April 2023 to March 2024 were selected as the research objects.According to different treatment schemes,they were divided into control group(n=33)and observation group(n=37).The control group was treated with routine treatment,and the observation group was treated with dapagliflozin on the basis of the control group.The clinical treatment ef⁃fect,blood glucose levels and cardiac function related indexes of the two groups were compared.Results The effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose and gly⁃cated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The left ventricular ejection fraction and cardiac output in the observation group were higher than those in the control group,and the N-terminal pro-brain natriuretic peptide was lower than that in the control group,and the differences were statistically significant(all P<0.05).Conclusion In the treatment of type 2 diabetes mellitus complicated with congestive heart failure,dapagliflozin can improve the blood glucose level and car⁃diac function of patients,and has high safety and significant therapeutic effect.