血清PRL和IL-38与2型糖尿病合并非酒精性脂肪肝病的相关性分析

Correlation of serum PRL and IL-38 with type 2 diabetes mellitus combined with non-alcoholic fatty liver disease

目的探讨血清催乳素(PRL)和白细胞介素-38(IL-38)与2型糖尿病(T2DM)合并非酒精性脂肪肝病(NAFLD)的相关性分析。方法选取2021年1月至2023年1月该院消化内科收治的T2DM患者172例为T2DM组,根据是否合并NAFLD分为NAFLD组(88例)和非NAFLD组(84例),另选取同期于该院进行健康体检的67例体检健康者为对照组。采用酶联免疫吸附试验检测血清PRL和IL-38水平,通过Logistic回归分析影响T2DM合并NAFLD的因素,采用受试者工作特征(ROC)曲线分析血清PRL和IL-38对T2DM合并NAFLD的预测价值。结果与对照组比较,T2DM组血清PRL水平降低,IL-38水平升高,差异均有统计学意义(P<0.05)。172例T2DM患者中NAFLD合并率为51.16%(88/172)。与非NAFLD组比较,NAFLD组血清PRL水平降低,IL-38水平升高(P<0.05)。体重指数增加、T2DM病程延长,以及天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、IL-38升高为T2DM合并NAFLD的独立危险因素(P<0.05),高密度脂蛋白胆固醇、PRL升高为独立保护因素(P<0.05)。血清PRL和IL-38联合预测T2D M合并NAFLD的曲线下面积为0.897,大于血清PRL、IL-38单独预测的0.779、0.782(P<0.05)。结论T2DM患者血清PRL水平降低,IL-38水平升高,是T2DM合并NAFLD的独立影响因素,血清PRL和IL-38联合检测对T2DM合并NAFLD有较高的预测价值。

Objective To investigate the correlation of serum oxytocin(PRL)and interleukin-38(IL-38)with type 2 diabetes mellitus(T2DM)combined with non-alcoholic fatty liver disease(NAFLD).Methods A total of 172 patients with T2DM admitted to the Department of Gastroenterology in the hospital from January 2021 to January 2023 were selected as the T2DM group and were divided into the NAFLD group(88 cases)and the non-NAFLD group(84 cases)according to whether or not they were comorbid with NAFLD,and 67 physically examined healthy people during the same period were also selected as the control group.Serum PRL and IL-38 levels were measured by enzyme-linked immunosorbent assay.Logistic regression was used to analyze the factors affecting T2DM combined with NAFLD,and receiver operating characteristic(ROC)curve was used to a nalyze the predictive value of serum PRL and IL-38 for T2DM combined with NAFLD.Results Compared with the control group,serum PRL levels decreased and IL-38 levels increased in the T2DM group(P<0.05).The NAFLD comorbidity rate was 51.16%(88/172)in 172 patients with T2DM.Compared with the non-NAFLD group,serum PRL levels decreased and IL-38 levels increased in the NAFLD group(P<0.05).Increased body mass index,prolonged duration of T2DM,and elevated ghrelin aminotransferase,ghrelin aminotransferase,total cholesterol,triacylglycerol,LDL cholesterol,and IL-38 were the independent risk factors for T2DM combined with NAFLD(P<0.05),and elevated HDL cholesterol and PRL were the independent protective factors(P<0.05).The area under the curve for the combined prediction of serum PRL and IL-38 for T2DM combined with NAFLD was 0.897,which was greater than 0.779 and 0.782 of serum PRL and IL-38 alone(P<0.05).Conclusion Reduced serum PRL levels and increased IL-38 levels in T2DM patients are independent influencing factors for T2DM combined with NAFLD,and the combination of serum PRL and IL-38 has a high predictive value for T2DM combined with NAFLD.