摘要
心血管疾病(CVD)是我国的一大公共卫生挑战,其发病率和病死率在逐年攀升。巨噬细胞代谢重编程在CVD中的影响日益受到重视,因为它直接关联到疾病的发病机制和潜在治疗策略。谷氨酰胺(GLN)作为巨噬细胞最主要的能量来源之一,其代谢改变直接影响了巨噬细胞的表型转换、功能执行以及在CVD中的适应性反应。该综述围绕巨噬细胞内的GLN代谢重编程对CVD发病机制的影响展开论述,探讨其在动脉粥样硬化、心肌梗死以及其他心血管病变中的作用,并评估调节GLN代谢路径作为治疗策略的潜力。
Cardiovascular disease(CVD)poses a significant public health challenge in China,with both incidence and mortality rates increasing.The role of macrophage metabolic reprogramming in CVD has garnered growing attention due to its direct connection to the pathogenesis of the disease and potential therapeutic interven‐tions.Glutamine(GLN),a fundamental energy source for macrophages,plays a crucial role in this context.Altera‐tions in GLN metabolism have substantial effects on macrophage phenotypic transformation,functional performance,and adaptive responses in the context of CVD.Therefore,this review aims to investigate the impact of GLN metabolic reprogramming on macrophages'contribution to the pathogenesis of CVD,specifically focusing on its involvement in atherosclerosis,myocardial infarction,and other cardiovascular conditions.Additionally,it will evaluate the poten‐tial of targeting GLN metabolic pathways as a therapeutic strategy.
作者
陈幸
邓燕
CHEN Xing;DENG Yan(Department of Ultrasound,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)
出处
《实用医学杂志》
CAS
北大核心
2024年第22期3262-3267,共6页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:82060051)
广西自然科学基金项目(编号:2023GXNSFAA026173)。
关键词
谷氨酰胺代谢
巨噬细胞
心血管疾病
代谢重编程
glutamine metabolism
macrophages
cardiovascular disease
metabolic reprogramming