四君子汤合四逆汤联合化疗治疗脾肾阳虚型肺癌效果观察

Effect of Sijunzi Decoction and Sini Decoction Combined with Chemotherapy on Lung Cancer of Spleen-kidney Yang Deficiency Type

目的:分析四君子汤合四逆汤联合化疗治疗脾肾阳虚型肺癌的临床效果。方法:选取2021年3月—2023年10月汕尾逸挥基金医院收治的60例脾肾阳虚型肺癌患者为研究对象,随机分为中药联合组和常规化疗组,各30例。常规化疗组应用化疗方案干预,中药联合组在常规化疗组基础上联合四君子汤合四逆汤干预。对比两组中医证候评分,瘤体体积变化,贫血、骨髓抑制情况以及生活质量。结果:治疗后,中药联合组中医证候评分低于治疗前,且低于常规化疗组(P<0.05)。中药联合组贫血、骨髓抑制发生率均低于常规化疗组(P<0.05);两组瘤体体积减小幅度对比,差异无统计学意义(P>0.05)。治疗后,两组精神健康、生理功能、社会功能、情感功能评分均升高,中药联合组高于常规化疗组(P<0.05)。结论:四君子汤合四逆汤联合化疗治疗脾肾阳虚型肺癌的效果较好,有利于缓解患者不适症状,减少贫血、骨髓抑制发生,提高生活质量。

Objective:To analyze the clinical effect of Sijunzi Decoction and Sini Decoction combined with chemotherapy on lung cancer of spleen-kidney Yang deficiency type.Methods:Sixty cases of lung cancer patients with spleen-kidney Yang deficiency treated in Shanwei Yihui Foundation Hospital from March 2021 to October 2023 were selected as the study objects and randomly divided into traditional Chinese medicine combination group and conventional chemotherapy group,with thirty cases in each group.The conventional chemotherapy group was treated with chemotherapy regimen,and traditional Chinese medicine combination group was treated with Sijunzi Decoction and Sini Decoction on the basis of conventional chemotherapy group.traditional Chinese medicine syndrome score,tumor volume change,anemia,myelosuppression and quality of life were compared between the two groups.Results:After treatment,the traditional Chinese medicine syndrome score in the traditional Chinese medicine combination group was lower than before treatment,and lower than that in the conventional chemotherapy group(P<0.05).The incidence of anemia and myelosuppression in traditional Chinese medicine combination group was lower than that in conventional chemotherapy group(P<0.05);there was no significant difference in tumor volume reduction between the two groups(P>0.05).After treatment,the scores of mental health,physiological function,social function and emotional function were increased in both groups,and those in traditional Chinese medicine combination group were higher than those in conventional chemotherapy group(P<0.05).Conclusion:Sijunzi Decoction combined with Sini Decoction combined with chemotherapy has a good effect in the treatment of spleen-kidney Yang deficiency type lung cancer,which is conducive to relieving patients'discomfort symptoms,reducing anemia and bone marrow suppression,and improving the quality of life.