《中药成方制剂》中含桂枝方剂的用药规律分析

An analysis of the medication rule of Chinese patent drugs containing Guizhi in national standard for Chinese patent drugs

目的:分析《中药成方制剂》中含桂枝方剂的用药规律。方法:应用中医传承辅助平台(V2.5)软件筛选符合要求的方剂,构建处方数据库,通过数据挖掘方法对处方中含桂枝方剂的主治疾病、证候、组方配伍等进行分析,并选取高频药对及高频疾病、高频证候进行药物组合的深度分析。结果:通过170首方剂的分析,得出含桂枝方剂主治疾病70种,以痹病、跌打损伤、感冒为主;证候类型有55种,以风寒湿凝滞筋骨、伤损筋骨、风寒束表证为主;与桂枝联用的高频次药物有甘草、当归、防风、麻黄、川芎等;常用药对有15个,出现频次最多的药对是“甘草-桂枝”,其次是“当归-桂枝”。通过纵横比较,得出桂枝常与补血活血药、发散风寒药、祛风除湿药联用。治疗痹病、感冒的方剂分别为独活寄生汤、麻黄汤的加减方。结论:桂枝具有多种功效与作用,能与不同的药物联用以治疗多种疾病,其中“甘草-桂枝”药对在心系疾病治疗中效果显著。桂枝治疗不同的疾病时配伍不同的药物,发挥不同的功效。桂枝在治疗不同证候时,配伍的药物有相似之处,亦有一定区别。对桂枝进行合理的配伍可优化组合,发挥整合作用,提高临床疗效。

Objective:The medication rule of TCM prescriptions containing Guizhi(Ramulus Cinnamomi)in the national standard for Chinese patent drugs was analyzed in this paper.Methods:By Traditional Chinese Medicine Inheritance Support System(V2.5),a prescription database was constructed by screening the prescription that met the requirements.Through data mining,the main treatment diseases,TCM syndromes,and compatibility features of prescriptions containing Guizhi were analyzed for in-depth analyses of medicine combination of high-frequency medicine pairs,high-frequency diseases and high-frequency syndromes.Results:There were 70 kinds of diseases were treated by the prescriptions containing Guizhi after the analysis of 170 prescriptions,among which Bi(痹)syndrome,bruises and colds were the main diseases.There were 55 kinds of syndrome types,mainly wind-cold-dampness stagnation of sinews and bones,injuries to sinews and bones,and wind-cold fettering the exterior.The high-frequency medicines used in combination with Guizhi were Gancao(Radix Glycyrrhizae),Danggui(Radix Angelicae Sinensis),Fangfeng(Radix Saposhnikoviae),Mahuang(Herba Ephedrae),Chuanxiong(Rhizoma Chuanxiong),etc..There were 15 commonly used medicine pairs,and the most frequent medicine pair was Gancao-Guizhi,followed by Danggui-Guizhi.Through vertical and horizontal comparisons,it was concluded that Guizhi was often used in combination with tonifying blood and promoting blood circulation medicines,dispersing wind-cold medicines,and eliminating wind-dampness medicines.The prescriptions for treating By syndrome and colds were the addition or subtractions of the Duhuo Jisheng decoction(独活寄生汤)and the Mahuang decoction(麻黄汤),respectively.Conclusion:Guizhi has a variety of effects and functions,and can be combined with different medicines to treat a variety of diseases,among which couplet medicines Gancao-Guizhi are very effective in the treatment of heart diseases.In the treatment of different diseases,Guizhi can be combined with different medicines to gain different effects.In the treatment of different syndromes,there are some similarities or differences in the medicine compatibility of Guizhi.Reasonable compatibility of Guizhi can optimize the combination,play an integrated role,so as to improve the clinical efficacy.