基于文献计量学的银杏叶提取物药效学、药代动力学研究热点与趋势分析

Analysis on research hotspots and future trends of Ginkgo biloba extract based on bibliometrics

目的:对银杏叶提取物药学研究领域进行研究现状、主题演化和热点趋势分析,为今后的研究提供依据和参考。方法:收集Web of Science核心合集数据集关于银杏叶提取物相关药学研究领域的文献数据,使用R Bibliometrix包、VOSviewer和CiteSpace等软件对发文趋势、作者、机构、国家、关键词和主题演化等内容进行文献计量和可视化分析。结果:最终纳入共514篇相关文献,年发文量趋势整体呈波动上升态势,近十年来上升迅速;该领域高影响力作者与研究机构之间存在广泛的合作关系;中国发文量占据绝对数量,中美间合作最为高频,中、美、法、韩之间的多国合作网络关系相对密切。对近十年高频关键词聚类得到14个聚类群和16种聚类突现词,主题词时间变化趋势表明银杏叶领域从多元化发展阶段走向逐步聚焦和深入分子机制的阶段。结论:银杏叶提取物研究已呈现从传统中医药研究向中西医结合、新型技术应用与结合的方向深入发展的态势。

Objective:To analyze the current research status,theme evolution and future frontiers of Ginkgo biloba extract in the pharmaceutical research field so as to provide evidence and references for future study.Methods:Literature data on Ginkgo biloba extract was extracted and filtered from Web of Science Core Collection,and R Bibliometrix,VOSviewer,CiteSpace were implemented to carry out statistical and visual analysis on publication trend,authors,institutions,countries,keywords,outburst words and future trends.Results:A total of 514 references were eventually incorporated.The number of annual publications showed a fluctuating rise overall and increased rapidly in the last decade.Broadly collaboration was observed between core authors and institutions with high impact;China led the high number of publications and maintained extensive cooperation with the United States,and the multinational collaboration network between China,the United States,France and the Republic of Korea was relatively close.Comprehensive analysis on keywords and research theme screened out 14 clusters and 16 keywords with the strongest citation bursts,and the thematic evolution indicated that the study on Ginkgo biloba extract has developed from the traditional research for herbal pharmacology to a new era digging deep into the molecular mechanism.Conclusion:The research on Ginkgo biloba extract presents a trend of in-depth development from the research of traditional Chinese medicine to the integration of traditional Chinese and Western medicine,and the application and combination of new technologies.