间充质干细胞在骨免疫中的研究进展

Research progress of mesenchymal stem cells in osteoimmunity

间充质干细胞(MSC)具有增殖、多向分化潜能和免疫调节功能。目前已经在多种组织中发现并分离出MSC,并可通过体外培养、诱导得到具有生物活性的细胞及其产物。更重要的是,MSC还具有免疫调节功能,在干细胞移植治疗骨损伤相关疾病中具有重要作用。因此,本文从MSC本身生物学特性和相关功能的角度,讨论了其在骨免疫中的作用及其治疗骨损伤疾病的机制,这将有助于全面了解MSC在生理病理状态下的功能。

Mesenchymal stem cells(MSCs)have the potential for proliferation,multidirectional differentiation and immune regulation.At present,MSCs have been found and isolated from a variety of tissues.Because of their biological characteristics of proliferation,migration and differentiation in vitro,they can be cultured and induced to obtain biologically active cells and their products.More importantly,MSCs also have immunomodulatory functions and play an important role in the treatment of bone injury-related diseases by stem cell transplantation.Therefore,from the perspective of biological characteristics and related functions of MSCs,this article discusses the role of MSCs in osteoimmunity and the mechanism of treatment of bone injury diseases,which will help to fully understand the function of MSCs in physiological and pathological states.