生物材料改性策略诱导骨微环境中免疫应答的研究进展

Research progress of biomaterial modification strategies to induce immune response in bone microenvironment

当前生物材料普遍存在免疫调控缺陷问题,无法很好诱导利于骨缺损修复的免疫微环境限制了其广泛应用。通过对生物材料各种理化性质的改性策略研究,积极主动调控骨微环境免疫应答是解决问题的关键。本文从当前骨缺损生物材料结构与成分改性、表面改性和负载免疫活性因子改性策略入手,对孔径与孔隙结构、掺杂材料(金属)、表面形态、表面电荷、表面亲水性与疏水性、表面粗糙度以及负载不同免疫活性因子诱导骨微环境中免疫应答的研究进展进行总结,以期为进一步开发具有良好骨免疫调节特性的生物材料提供启示与思考。

Currently,there is a prevalent issue of immune regulation defects in biological materials,which hinders their widespread application for promoting bone defect repair due to the inability to induce a favorable immune microenvironment.The key to solving this problem lies in actively modulating the immune response in the bone microenvironment by modifying various physicochemical properties of biomaterials.This paper reviews the research progress on modifying biomaterials through strategies such as structural and compositional adjustments,surface enhancements,and modifications with loaded immunoreactive factors.Specifically,it focuses on pore size and structure,dopant materials(metal),surface morphology,charge,hydrophilicity and hydrophobicity,roughness,and loading with different immunoreactive factors to induce immune responses within the bone microenvironment.The aim is to offer insights for the further development of biomaterials with superior immunomodulatory properties.