成红细胞岛在红系发育及相关疾病中的研究进展

Research progress on erythroblastic islands in erythroid development and related diseases

成红细胞岛(EBI)是成红细胞发育成熟过程中形成的特殊结构,由成红细胞围绕一个中央巨噬细胞组成。其中巨噬细胞在介导EBI形成以及成红细胞增殖分化、脱核成熟过程中发挥重要的调控作用。在应激状态下,二者之间黏附分子表达异常将导致多种红系疾病的发生。提示靶向EBI中的中央巨噬细胞有望成为治疗红系疾病的新策略。文章归纳总结了EBI的结构功能、巨噬细胞和成红细胞相互作用以及EBI内中央巨噬细胞在红系疾病中的作用和治疗潜力,为临床治疗红系疾病提供新思路。

Erythroblastic islands(EBIs)are specialized structures that are formed by a central macrophage surrounded by maturating erythroblasts.The central macrophage mediates EBI formation and plays a crucial role in the proliferation,differentiation,enucleation,and maturation of erythroblasts.In stress erythropoiesis,the expression levels of several adhesion molecules mediating EBI formation become abnormal,leading to various erythroid diseases.These findings have indicated that targeting central macrophages may become a new therapeutic approach for treating erythroid diseases.This review summarizes the structure and function of EBIs,macrophage-erythroblast interactions in EBIs,and potential therapeutic direction of EBI central macrophages for erythroid diseases,providing new insights for the clinical treatment of erythroid diseases.