调节性T细胞/Th17细胞平衡在肌骨衰减及重建中作用的研究进展

Research progress on the role of regulatory T cells/Th17 cells balance in muscle-bone degeneration and reconstruction

肌肉减少症和骨质疏松症并不是独立发展的疾病,相反二者之间存在密切的生理病理关系,常伴随发生(即肌骨共减综合征),这种生理病理联系也为探析肌肉再生和骨骼重塑的共同机制提供了基础。在肌骨衰减过程中,炎症作用是疾病发展的重要机制,而调节性T细胞(Treg)/Th17细胞比值是免疫平衡炎症反应的重要调节机制。如果Treg数量和功能受损,而Th17细胞的活性增强,将会造成Treg与Th17细胞之间的平衡失调,导致炎症反应的增加和组织损伤的累积,最终导致成肌和成骨功能受损。通过调节Treg/Th17细胞免疫平衡则可以改善肌骨衰减的症状。

Sarcopenia and osteoporosis do not develop independently.Rather,there is a close physiological and pathological relationship between them,often leading to the condition known as osteo-sarcopenia.This relationship also provides a basis for exploring the common mechanisms of muscle regeneration and bone remodeling.In the process of muscle and bone degeneration,inflammation is an important mechanism for disease progression,and the balance between regulatory T cells(Tregs)and Th17 cells is an important regulatory mechanism for immune equilibrium and inflammatory response.If the number and function of Tregs are impaired,coupled with an increase in the activity of Th17 cells,an imbalance between Tregs and Th17 cells occurs,leading to an increase in inflammatory response and an accumulation of tissue damage,and ultimately impairing myogenic and osteogenic functions.By regulating the Treg/Th17 cell immune balance,symptoms of muscle and bone degeneration can be improved.