红曲制剂对高脂血症患者血清APOB、LDL⁃C及瘦素水平的影响及与动脉粥样硬化的关系

Effect of monascus preparation on serum APOB, LDL⁃C and leptin levels in patients with hyperlipidemia and its relationship with atherosclerosis

目的分析红曲制剂对高脂血症患者血清载脂蛋白B(APOB)、低密度脂蛋白胆固醇(LDL⁃C)及瘦素水平的影响及与动脉粥样硬化的关系。方法选取2020年1月至2022年9月郑州大学附属郑州中心医院收治的151例高血脂症伴动脉粥样硬化性心血管疾病风险患者作为研究对象,根据治疗方案不同分为对照组75例(予以阿托伐他汀钙片)与观察组76例(予以脂必泰胶囊)。比较两组APOB、LDL⁃C、瘦素水平、动脉粥样硬化指标、心脑血管事件发生率、并发症发生率,采用Pearson相关性分析APOB、LDL⁃C、瘦素与动脉粥样硬化的相关性。结果经治疗后,两组APOB、LDL⁃C、瘦素水平均下降,且观察组治疗12、18个月后的APOB、LDL⁃C、瘦素水平水平均低于对照组,差异有统计学意义(P<0.05);冠状动脉钙化积分、颈动脉内膜中层厚度:治疗18个月后<治疗12个月后<治疗前,差异有统计学意义(P<0.05);Pearson相关性分析结果显示:APOB、LDL⁃C、瘦素与冠状动脉钙化积分、颈动脉内膜中层厚度呈正相关(P<0.05);观察组在治疗期间出现的心脑血管事件总发生率以及不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论APOB、LDL⁃C、瘦素与动脉粥样硬化发生、发展有一定关联,红曲制剂脂必泰胶囊可有效改善高脂血症伴随颈动脉粥样硬化患者脂肪代谢功能、动脉粥样硬化情况,减少心脑血管事件发生率,安全性尚可。

Objective To analyze the effect of monascus preparation on serum apolipoprotein B(APOB),low⁃density lipoprotein cholesterol(LDL⁃C)and leptin levels in patients with hyperlipidemia and the relationship between monascus preparation and atherosclerosis.Methods A total of 151 patients with hyperlipidemia and atherosclerotic cardiovascular disease risk were admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2020 to September 2022 and were selected as the research subjects.They were divided into two groups based on different treatment regimens:the control group(75 cases treated with atorvastatin calcium tablets)and the observation group(76 cases treated with Zhibitai capsule).The levels of APOB,LDL⁃C,leptin,atherosclerosis index,incidence of cardiovascular and cerebrovascular events,and incidence of complications were compared between the two groups.Additionally,the correlation between APOB,LDL⁃C,leptin,and atherosclerosis was analyzed using the Pearson correlation coefficient.Results After a prolonged period of treatment,the levels of APOB,LDL⁃C,and leptin in the two groups decreased.The levels of APOB,LDL⁃C,and leptin in the observation group after 12 and 18 months of treatment were lower than those in the control group(P<0.05).The coronary artery calcification score and carotid intima⁃media thickness were as follows:18 months after treatment<12 months after treatment<before treatment(P<0.05).According to Pearson correlation analysis,APOB,LDL⁃C,and leptin were positively correlated with the coronary artery calcification score and carotid intima⁃media thickness(P<0.05).The total incidence of cardiovascular and cerebrovascular events and adverse reactions in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion APOB,LDL⁃C,and leptin are related to the occurrence and development of atherosclerosis to a certain extent.Zhibitai capsule,a preparation of monosaccharide,can effectively improve fat metabolism and atherosclerosis in patients with hyperlipidemia accompanied by carotid atherosclerosis.It can also reduce the incidence of cardiovascular and cerebrovascular events,with reasonable safety.