不同生命周期女性乳腺癌临床病理特征研究

Clinicopathological characteristics of female breast cancer in different life cycles

目的分析不同生命周期女性乳腺癌患者的临床病理特征。方法收集安徽省芜湖市第一人民医院2019年1月至2023年12月188例女性浸润性乳腺癌患者的临床资料,按年龄不同分为生育期组、更年期组、绝经期组,对各组患者的临床病理特征进行统计学分析及研究。结果生育期组,较高肿瘤分期的比率、淋巴结转移率及较晚临床分期比率高于其他两组,差异有统计学意义(P<0.05)。组织学分型及组织学分级在各组之间差异无统计学意义(P>0.05)。生育期组,ER阳性率低于其他两组,Ki⁃67高表达比例高于其他两组,差异有统计学意义(P<0.05)。PR阳性率、HER⁃2状态及分子分型各组间差异无统计学意义(P<0.05)。结论与其他生命周期乳腺癌相比,生育期乳腺癌临床分期较晚、淋巴结转移率高,具有更强侵袭性,在预防和治疗等方面,应和其他生命周期乳腺癌有所不同。

Objective To analyze the clinicopathological characteristics of female breast cancer patients in different life cycles.Methods The clinical data of 188 women with invasive breast cancer were collected and divided into the fertility group,the menopause group and the menopause group according to age.Results In the reproductive age group,the rates of higher tumor staging,lymph node metastasis,and later clinical staging were significantly higher compared to the other two groups(P<0.05).There was no statistically significant difference in organizational credit type and histological grading among the groups(P>0.05).Additionally,in the reproductive age group,the ER positivity rate was lower than the other two groups,and the proportion of Ki⁃67 high expression was higher than the other two groups,with statistical significance(P<0.05).There were no significant differences in PR positivity rate,HER⁃2 status,and molecular typing among the groups(P>0.05).Conclusion Compared to breast cancer in other stages of life,breast cancer during the reproductive period tends to present at a later clinical stage and has a higher rate of lymph node metastasis,indicating a more aggressive nature.Therefore,it should be approached differently in terms of prevention and treatment compared to breast cancer at other stages of life.