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真菌感染对寻常性银屑病患者TLR7、IL⁃23、IL⁃17信号通路的影响

Effects of fungal infection on TLR7,IL⁃23 and IL⁃17 signaling pathways in patients with psoriasis vulgaris
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摘要 目的探讨分析真菌感染对寻常性银屑病(PV)患者Toll样受体7(TLR7)、白细胞介素⁃23(IL⁃23)、白细胞介素⁃17(IL⁃17)信号通路的影响。方法选取黑龙江中医药大学皮肤病科2022年6月至2023年6月收治的100例PV患者进行分析,根据是否并发真菌感染分为感染组41例及正常组59例。比较两组患者皮损面积及严重程度指数(PASI)、免疫功能[T淋巴细胞亚群(CD4^(+)、CD8^(+))、免疫球蛋白(Ig)A、IgG]及炎症因子[肿瘤坏死因子α(TNF⁃α)、干扰素⁃γ(IFN⁃γ)、IL⁃23、IL⁃17]水平,比较两组TLR7 mRNA表达量和蛋白表达量,通过Spearman分析TLR7、IL⁃23、IL⁃17与PASI的相关性。结果感染组PASI评分及CD4^(+)、CD8^(+)、IgA、IgG均高于正常组,差异有统计学意义(P<0.05);感染组TNF⁃α、IFN⁃γ、IL⁃23、IL⁃17、TLR7 mRNA表达量和蛋白表达量高于正常组,差异有统计学意义(P<0.05);经Spearman相关性分析显示,PASI及CD4^(+)、CD8^(+)、IgG、IgA与TLR7蛋白表达量呈正相关(P<0.05),与TLR7 mRNA表达量呈正相关(P<0.05),与IL⁃23呈正相关(P<0.05)、与IL⁃17呈正相关(P<0.05)。结论真菌感染后PV患者单个核细胞TLR7表达量及血清IL⁃23、IL⁃17水平升高,且与机体免疫炎症状态及病情密切相关。 Objective To investigate the effects of fungal infection on Toll⁃like receptor 7(TLR7),interleukin⁃23(IL⁃23)and interleukin⁃17(IL⁃17)signaling pathways in patients with psoriasis vul⁃garis(PV).Methods 100 cases of PV patients were admitted to the Department of Dermatology,at Heilongjiang University of Chinese Medicine from June 2022 to June 2023.They were retrospectively analyzed and divided into two groups:the infected group(41 cases)and the normal group(59 cases)based on whether they were complicated by fungal infection.The skin area and severity index(PASI),immune function[T lymphocyte subsets(CD4^(+),CD8^(+))were compared between the two groups/CD8^(+)],immunoglobulin(Ig)A,IgG and inflammatory factors[tumor necrosis factorα(TNF⁃α),interferon⁃γ(IFN⁃γ),IL⁃23,IL⁃17]levels.TLR7 mRNA expression and protein expression levels were compared between the two groups.The correlation between TLR7,IL⁃23,IL⁃17 and PASI was analyzed using Spearman's correlation.Results The PASI score,CD4^(+),CD8^(+),IgA,and IgG levels in the infected group were higher than those in the normal group,with statistical significance(P<0.05).The mRNA and protein expressions of TNF⁃α,IFN⁃γ,IL⁃23,IL⁃17,and TLR7 in the infection group were higher than those in normal group,with statistical significance(P<0.05).Spearman correlation analysis showed that PASI,CD4^(+),CD8^(+),IgG,IgA,and TLR7 protein expression were positively correlated(P<0.05).There was a positive correlation with TLR7 mRNA expression(P<0.05),and a positive correlation with IL⁃23(P<0.05),was positively correlated with IL⁃17(P<0.05).Conclusion The expression of TLR7 in mononuclear cells and the levels of IL⁃23 and IL⁃17 in the serum of PV patients after fungal infection were increased,which was closely related to the immune inflammatory state and overall disease progression in the body.
作者 张译丹 董晓仪 王人可 王和平 ZHANG Yidan;DONG Xiaoyi;WANG Renke;WANG Heping(Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,China,150040;Academy of Sciences,Heilongjiang Provincial Hospital of Traditional Chinese Medicine,Harbin,Heilongjiang,China,150040;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongji-ang,China,150040)
出处 《分子诊断与治疗杂志》 2024年第11期2169-2172,共4页 Journal of Molecular Diagnostics and Therapy
基金 黑龙江中医药大学研究生创新科研项目立项(2024yjscx033)。
关键词 真菌感染 寻常性银屑病 TOLL样受体7 白细胞介素⁃23 白细胞介素⁃17 Fungal infection Psoriasis vulgaris Toll⁃like receptor 7 Interleukin⁃23 Interleukin⁃17
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